1cix

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[[Image:1cix.gif|left|200px]]
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{{STRUCTURE_1cix| PDB=1cix | SCENE= }}
{{STRUCTURE_1cix| PDB=1cix | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF ANTIMICROBIAL PEPTIDE TACHYSTATIN A ISOLATED FROM HORSESHOE CRAB'''
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===THREE-DIMENSIONAL STRUCTURE OF ANTIMICROBIAL PEPTIDE TACHYSTATIN A ISOLATED FROM HORSESHOE CRAB===
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==Overview==
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The solution structure of antimicrobial peptide tachystatin A from the Japanese horseshoe crab (Tachypleus tridentatus) was determined by two-dimensional nuclear magnetic resonance measurements and distance-restrained simulated annealing calculations. The correct pairs of disulfide bonds were also confirmed in this study. The obtained structure has a cysteine-stabilized triple-stranded beta-sheet as a dominant secondary structure and shows an amphiphilic folding observed in many membrane-interactive peptides. Interestingly, tachystatin A shares structural similarities with the calcium channel antagonist omega-agatoxin IVA isolated from spider toxin and mammalian defensins, and we predicted that omega-agatoxin IVA also have the antifungal activity. These structural comparisons and functional correspondences suggest that tachystatin A and omega-agatoxin IVA may exert the antimicrobial activity in a manner similar to defensins, and we have confirmed such activity using fungal culture assays. Furthermore, tachystatin A is a chitin-binding peptide, and omega-agatoxin IVA also showed chitin-binding activities in this study. Tachystatin A and omega-agatoxin IVA showed no structural homology with well known chitin-binding motifs, suggesting that their structures belong to a novel family of chitin-binding peptides. Comparison of their structures with those of cellulose-binding proteins indicated that Phe(9) of tachystatin A might be an essential residue for binding to chitin.
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{{ABSTRACT_PUBMED_11959852}}
==About this Structure==
==About this Structure==
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1CIX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIX OCA].
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1CIX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIX OCA].
==Reference==
==Reference==
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[[Category: Antimicrobial peptide]]
[[Category: Antimicrobial peptide]]
[[Category: Chitin-binding peptide]]
[[Category: Chitin-binding peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:46:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:48:33 2008''

Revision as of 17:48, 30 June 2008

Image:1cix.png

Template:STRUCTURE 1cix

THREE-DIMENSIONAL STRUCTURE OF ANTIMICROBIAL PEPTIDE TACHYSTATIN A ISOLATED FROM HORSESHOE CRAB

Template:ABSTRACT PUBMED 11959852

About this Structure

1CIX is a Single protein structure of sequence from Tachypleus tridentatus. Full experimental information is available from OCA.

Reference

Structure of the antimicrobial peptide tachystatin A., Fujitani N, Kawabata S, Osaki T, Kumaki Y, Demura M, Nitta K, Kawano K, J Biol Chem. 2002 Jun 28;277(26):23651-7. Epub 2002 Apr 16. PMID:11959852

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