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1cj1

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{{STRUCTURE_1cj1| PDB=1cj1 | SCENE= }}
{{STRUCTURE_1cj1| PDB=1cj1 | SCENE= }}
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'''GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE'''
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===GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE===
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==Overview==
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Previous efforts in the search for molecules capable of blocking the associations between the activated tyrosine kinase growth factor receptors and the SH2 domain of Grb2 had resulted in the identification of 3-amino-Z-pTyr-Ac6c-Asn-NH2, a high-affinity and selective antagonist of this SH2 domain. In the present paper, we report the successful replacement of asparagine in this compound by a beta-amino acid mimetic, which brings us closer to our objective of identifying a Grb2-SH2 antagonist suitable for pharmacological investigations.
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(as it appears on PubMed at http://www.pubmed.gov), where 10395476 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10395476}}
==About this Structure==
==About this Structure==
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[[Category: Sh2 domain]]
[[Category: Sh2 domain]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:47:07 2008''
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Revision as of 17:49, 30 June 2008

Image:1cj1.png

Template:STRUCTURE 1cj1

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

Template:ABSTRACT PUBMED 10395476

About this Structure

1CJ1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic., Furet P, Garcia-Echeverria C, Gay B, Schoepfer J, Zeller M, Rahuel J, J Med Chem. 1999 Jul 1;42(13):2358-63. PMID:10395476

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