1cjf

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[[Image:1cjf.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1cjf| PDB=1cjf | SCENE= }}
{{STRUCTURE_1cjf| PDB=1cjf | SCENE= }}
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'''PROFILIN BINDS PROLINE-RICH LIGANDS IN TWO DISTINCT AMIDE BACKBONE ORIENTATIONS'''
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===PROFILIN BINDS PROLINE-RICH LIGANDS IN TWO DISTINCT AMIDE BACKBONE ORIENTATIONS===
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==Overview==
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The actin regulatory protein profilin is targeted to specific cellular regions through interactions with highly proline-rich motifs embedded within its binding partners. New X-ray crystallographic results demonstrate that profilin, like SH3 domains, can bind proline-rich ligands in two distinct amide backbone orientations. By further analogy with SH3 domains, these data suggest that non-proline residues in profilin ligands may dictate the polarity and register of binding, and the detailed organization of the assemblies involving profilin. This degeneracy may be a general feature of modules that bind proline-rich ligands, including WW and EVH1 domains, and has implications for the assembly and activity of macromolecular complexes involved in signaling and the regulation of the actin cytoskeleton.
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(as it appears on PubMed at http://www.pubmed.gov), where 10404225 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10404225}}
==About this Structure==
==About this Structure==
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[[Category: Poly-l-proline]]
[[Category: Poly-l-proline]]
[[Category: Profilin]]
[[Category: Profilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:47:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:50:00 2008''

Revision as of 17:50, 30 June 2008

Image:1cjf.png

Template:STRUCTURE 1cjf

PROFILIN BINDS PROLINE-RICH LIGANDS IN TWO DISTINCT AMIDE BACKBONE ORIENTATIONS

Template:ABSTRACT PUBMED 10404225

About this Structure

1CJF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Profilin binds proline-rich ligands in two distinct amide backbone orientations., Mahoney NM, Rozwarski DA, Fedorov E, Fedorov AA, Almo SC, Nat Struct Biol. 1999 Jul;6(7):666-71. PMID:10404225

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