Mitogen-activated protein kinase kinase 3D structures

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*MAP2K1; Domains – PB1 2-124; kinase 62-393
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*MAP2K1 or Mek1; Domains – PB1 2-124; kinase 62-393; TOG 548-867
**[[3mbl]], [[3e8n]], [[3dy7]], [[3eqb]], [[2p55]], [[4ark]] – hMAP2K1 kinase domain +MgADP+ligand - human<br />
**[[3mbl]], [[3e8n]], [[3dy7]], [[3eqb]], [[2p55]], [[4ark]] – hMAP2K1 kinase domain +MgADP+ligand - human<br />
 +
**[[6nyb]], [[6q0j]], [[6q0t]] – hMAP2K1 in MAPK pathway comples – Cryo EM<br />
 +
**[[6whb]] – hMAP2K1 TOG domain<br />
**[[3eqc]] – hMAP2K1 kinase domain+ATP-Gs+Mg2P<br />
**[[3eqc]] – hMAP2K1 kinase domain+ATP-Gs+Mg2P<br />
**[[3eqd]] - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P<br />
**[[3eqd]] - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P<br />
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**[[3eqh]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor<br />
**[[3eqh]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor<br />
**[[3orn]], [[4lmn]], [[3wig]] - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor<br />
**[[3orn]], [[4lmn]], [[3wig]] - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor<br />
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**[[3sls]] – hMAP2K1 kinase domain (mutant) + Mg + AMPPNP + inhibitor<br />
+
**[[3sls]] – hMAP2K1 kinase domain (mutant) + Mg + AMPPNP + inhibitor<br />
**[[4an2]], [[4an3]], [[4an9]], [[4anb]] – hMAP2K1 kinase domain (mutant) + Mg + ACP + inhibitor<br />
**[[4an2]], [[4an3]], [[4an9]], [[4anb]] – hMAP2K1 kinase domain (mutant) + Mg + ACP + inhibitor<br />
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**[[3zls]], [[3zlw]], [[3zlx]], [[3zly]], [[3zm4]] – hMAP2K1 kinase domain + inhibitor<br />
+
**[[3zls]], [[3zlw]], [[3zlx]], [[3zly]], [[3zm4]], [[5bx0]], [[5eym]], [[5hze]] – hMAP2K1 kinase domain + inhibitor<br />
**[[3os3]], [[3pp1]], [[3v01]], [[3v04]], [[3vvh]] - hMAP2K1 kinase domain + MgATP +inhibitor<br />
**[[3os3]], [[3pp1]], [[3v01]], [[3v04]], [[3vvh]] - hMAP2K1 kinase domain + MgATP +inhibitor<br />
 +
**[[7juq]] – hMAP2K1 kinase domain + ADP <br />
 +
**[[4u7z]], [[4u80]], [[4u81]], [[7b3m]], [[7b7r]], [[7b94]], [[7b9l]] – hMAP2K1 kinase domain + ANP + inhibitor<br />
 +
**[[5kkr]] – hMAP2K1 kinase domain + KSR2 + inhibitor<br />
 +
**[[7jur]], [[7jus]], [[7jut]], [[7juu]], [[7juv]], [[7juw]], [[7jux]], [[7juy]], [[7juz]], [[7jv0]], [[7jv1]] – hMAP2K1 kinase domain + KSR2 + ANP-PNP + inhibitor<br />
 +
**[[6u2g]], [[6v2w]] – hMAP2K1 + BRAF + AMP-PNP<br />
 +
**[[6pp9]], [[7m0t]], [[7m0u]], [[7m0v]], [[7m0w]], [[7m0x]], [[7m0y]], [[7m0z]] – hMAP2K1 + BRAF + AMP-PNP + inhibitor<br />
**[[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br />
**[[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br />
**[[3dv3]] - hMAP2K1 kinase domain +inhibitor<br />
**[[3dv3]] - hMAP2K1 kinase domain +inhibitor<br />
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**[[3cpt]] - hMAP2K1 PB1 domain +P14 (mutant)<br />
**[[3cpt]] - hMAP2K1 PB1 domain +P14 (mutant)<br />
**[[1vet]], [[1veu]] - mMAP2K1+P14 - mouse<br />
**[[1vet]], [[1veu]] - mMAP2K1+P14 - mouse<br />
 +
**[[2y4i]] – MAP2K1 + KSR2 + ATP – rabbit<br />
*MAP2K2
*MAP2K2
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*MAP2K4
*MAP2K4
 +
**[[3vut]] - hMAP2K4 kinase domain<br />
**[[3aln]] - hMAP2K4 kinase domain +AMPPNP<br />
**[[3aln]] - hMAP2K4 kinase domain +AMPPNP<br />
**[[3alo]] - hMAP2K4 kinase domain + P38 peptide
**[[3alo]] - hMAP2K4 kinase domain + P38 peptide
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**[[2o2v]] – hMAP2K5 PB1 domain + hMAP3K3B PB1 domain<br />
**[[2o2v]] – hMAP2K5 PB1 domain + hMAP3K3B PB1 domain<br />
**[[1wi0]] - mMAP2K5 PB1 domain – NMR<br />
**[[1wi0]] - mMAP2K5 PB1 domain – NMR<br />
 +
**[[1p38]], [[2npt]] – hMAP2K5+hMAP2KK2<br />
 +
**[[4ic7]] - hMAP2K4 kinase domain + MAPK7 + AMPPNP<br />
*MAP2K6
*MAP2K6
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*MAP2K7 kinase domain 101-421
*MAP2K7 kinase domain 101-421
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**[[6qfl]], [[6qfr]], [[6yfz]], [[6yg1]] – hMAP2K7<br />
+
**[[5b2k]], [[5b2l]], [[5b2m]], [[6qfl]], [[6qfr]], [[6yfz]], [[6yg0]], [[6yg1]] – hMAP2K7 kinase domain <br />
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**[[2dyl]], [[6yg0]] – hMAP2K7 (mutant)
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**[[2dyl]], [[5y8u]], [[5y90]] – hMAP2K7 kinase domain (mutant)<br />
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**[[6ib0]], [[6ib2]], [[6qft]], [[6qg4]], [[6qg7]], [[6qho]], [[6qhr]], [[6yg3]], [[6yg4]], [[6yg5]], [[6yg6]], [[6yg7]] – hMAP2K7 + inhibitor<br />
+
**[[3wzu]], [[6ib0]], [[6ib2]], [[6qft]], [[6qg4]], [[6qg7]], [[6qho]], [[6qhr]], [[6yg2]], [[6yg3]], [[6yg4]], [[6yg5]], [[6yg6]], [[6yg7]], [[6yz4]], [[7cbx]] – hMAP2K7 kinase domain + inhibitor<br />
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**[[6yg2]], [[6yz4]] – hMAP2K7 + drug<br />
+
**[[5z1d]], [[5z1e]] – hMAP2K7 kinase domain (mutant) + inhibitor<br />
 +
**[[4ux9]] - hMAP2K7 kinase domain + MAPK8 + AMPPNP<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:52, 4 November 2021

3D Structures of Mitogen-activated protein kinase kinase

Updated on 04-November-2021

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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