Monoamine oxidase
From Proteopedia
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'''Monoamine oxidas'''e (MAO) are enzymes which catalyze the oxidation of monoamines<ref>PMID:15279561</ref>. MAO contains FAD as co-factor.<br /> | '''Monoamine oxidas'''e (MAO) are enzymes which catalyze the oxidation of monoamines<ref>PMID:15279561</ref>. MAO contains FAD as co-factor.<br /> | ||
* '''MAO-A''' and '''MAO-C''' are human enzymes which oxidize adrenaline, noradrenaline, serotonin and dopamine.<br /> | * '''MAO-A''' and '''MAO-C''' are human enzymes which oxidize adrenaline, noradrenaline, serotonin and dopamine.<br /> | ||
| - | * '''MAO-B''' is a human enzyme which oxidizes benzylamine and phenylethylamine. For details on MAO-B see [[Monoamine oxidase b]].<br /> | + | * '''MAO-B''' or '''amine oxidase [flavin-containing] B''' is a human enzyme which oxidizes benzylamine and phenylethylamine. For details on MAO-B see [[Monoamine oxidase b]].<br /> |
* '''MAO-N''' is a ''Aspergillus niger'' enzyme which oxidizes primary amines<ref>PMID:18951902</ref>. | * '''MAO-N''' is a ''Aspergillus niger'' enzyme which oxidizes primary amines<ref>PMID:18951902</ref>. | ||
Revision as of 08:40, 6 October 2020
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3D structures of monoamine oxidase
Updated on 06-October-2020
References
- ↑ Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J. Monoamine oxidases: certainties and uncertainties. Curr Med Chem. 2004 Aug;11(15):1965-82. PMID:15279561
- ↑ Atkin KE, Reiss R, Koehler V, Bailey KR, Hart S, Turkenburg JP, Turner NJ, Brzozowski AM, Grogan G. The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution. J Mol Biol. 2008 Dec 31;384(5):1218-31. Epub 2008 Oct 14. PMID:18951902 doi:10.1016/j.jmb.2008.09.090
- ↑ Meyer JH, Ginovart N, Boovariwala A, Sagrati S, Hussey D, Garcia A, Young T, Praschak-Rieder N, Wilson AA, Houle S. Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry. 2006 Nov;63(11):1209-16. PMID:17088501 doi:http://dx.doi.org/10.1001/archpsyc.63.11.1209
- ↑ Caccia C, Maj R, Calabresi M, Maestroni S, Faravelli L, Curatolo L, Salvati P, Fariello RG. Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology. 2006 Oct 10;67(7 Suppl 2):S18-23. PMID:17030736
- ↑ Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A. Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4. PMID:17915852 doi:http://dx.doi.org/10.1021/jm070677y
