1ck2

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[[Image:1ck2.gif|left|200px]]
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{{STRUCTURE_1ck2| PDB=1ck2 | SCENE= }}
{{STRUCTURE_1ck2| PDB=1ck2 | SCENE= }}
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'''YEAST (SACCHAROMYCES CEREVISIAE) RIBOSOMAL PROTEIN L30'''
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===YEAST (SACCHAROMYCES CEREVISIAE) RIBOSOMAL PROTEIN L30===
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==Overview==
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The ribosomal protein L30 from yeast Saccharomyces cerevisiae auto-regulates its own synthesis by binding to a structural element in both its pre-mRNA and its mRNA. The three-dimensional structures of L30 in the free (f L30) and the pre-mRNA bound (b L30) forms have been solved by nuclear magnetic resonance spectroscopy. Both protein structures contain four alternating alpha-helices and four beta-strands segments and adopt an overall topology that is an alphabetaalpha three-layer sandwich, representing a unique fold. Three loops on one end of the alphabetaalpha sandwich have been mapped as the RNA binding site on the basis of structural comparison, chemical shift perturbation and the inter-molecular nuclear Overhauser effects to the RNA. The structural and dynamic comparison of f L30 and b L30 reveals that local dynamics may play an important role in the RNA binding. The fourth helix in b L30 is longer than in f L30, and is stabilized by RNA binding. The exposed hydrophobic surface that is buried upon RNA binding may provide the energy necessary to drive secondary structure formation, and may account for the increased stability of b L30.
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(as it appears on PubMed at http://www.pubmed.gov), where 10493880 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10493880}}
==About this Structure==
==About this Structure==
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1CK2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CK2 OCA].
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1CK2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CK2 OCA].
==Reference==
==Reference==
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[[Category: Auto-regulation of pre-mrna splicing and mrna translation]]
[[Category: Auto-regulation of pre-mrna splicing and mrna translation]]
[[Category: Ribosomal protein]]
[[Category: Ribosomal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:49:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:51:21 2008''

Revision as of 17:51, 30 June 2008

Image:1ck2.png

Template:STRUCTURE 1ck2

YEAST (SACCHAROMYCES CEREVISIAE) RIBOSOMAL PROTEIN L30

Template:ABSTRACT PUBMED 10493880

About this Structure

1CK2 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Local folding coupled to RNA binding in the yeast ribosomal protein L30., Mao H, Williamson JR, J Mol Biol. 1999 Sep 17;292(2):345-59. PMID:10493880

Page seeded by OCA on Mon Jun 30 20:51:21 2008

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