We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1ck4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ck4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ck4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ck4| PDB=1ck4 | SCENE= }}
{{STRUCTURE_1ck4| PDB=1ck4 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF RAT A1B1 INTEGRIN I-DOMAIN.'''
+
===CRYSTAL STRUCTURE OF RAT A1B1 INTEGRIN I-DOMAIN.===
-
==Overview==
+
<!--
-
The alpha1beta1 integrin is a major cell surface receptor for collagen. Ligand binding is mediated, in part, through a 200 amino acid inserted 'I'-domain contained in the extracellular part of the integrin alpha chain. Integrin I-domains contain a divalent cation binding (MIDAS) site and require cations to interact with integrin ligands. We have determined the crystal structure of recombinant I-domain from the rat alpha1beta1 integrin at 2.2 A resolution in the absence of divalent cations. The alpha1 I-domain adopts the dinucleotide binding fold that is characteristic of all I-domain structures that have been solved to date and has a structure very similar to that of the closely related alpha2beta1 I-domain which also mediates collagen binding. A unique feature of the alpha1 I-domain crystal structure is that the MIDAS site is occupied by an arginine side chain from another I-domain molecule in the crystal, in place of a metal ion. This interaction supports a proposed model for ligand-induced displacement of metal ions. Circular dichroism spectra determined in the presence of Ca2+, Mg2+ and Mn2+ indicate that no changes in the structure of the I-domain occur upon metal ion binding in solution. Metal ion binding induces small changes in UV absorption spectra, indicating a change in the polarity of the MIDAS site environment.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10386626}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10386626 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10386626}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: I-domain]]
[[Category: I-domain]]
[[Category: Metal binding]]
[[Category: Metal binding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:49:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:51:28 2008''

Revision as of 17:51, 30 June 2008

Image:1ck4.png

Template:STRUCTURE 1ck4

CRYSTAL STRUCTURE OF RAT A1B1 INTEGRIN I-DOMAIN.

Template:ABSTRACT PUBMED 10386626

About this Structure

1CK4 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain function., Nolte M, Pepinsky RB, Venyaminov SYu, Koteliansky V, Gotwals PJ, Karpusas M, FEBS Lett. 1999 Jun 11;452(3):379-85. PMID:10386626

Page seeded by OCA on Mon Jun 30 20:51:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ck4"
Personal tools