6xjx

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Current revision (14:50, 6 March 2024) (edit) (undo)
 
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====
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==MCU holocomplex in Low-calcium blocking state==
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<StructureSection load='6xjx' size='340' side='right'caption='[[6xjx]]' scene=''>
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<StructureSection load='6xjx' size='340' side='right'caption='[[6xjx]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6xjx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XJX FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjx OCA], [http://pdbe.org/6xjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xjx RCSB], [http://www.ebi.ac.uk/pdbsum/6xjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjx ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjx OCA], [https://pdbe.org/6xjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xjx RCSB], [https://www.ebi.ac.uk/pdbsum/6xjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCU_HUMAN MCU_HUMAN] Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.<ref>PMID:21685886</ref> <ref>PMID:21685888</ref> <ref>PMID:22822213</ref> <ref>PMID:22829870</ref> <ref>PMID:22904319</ref> <ref>PMID:23101630</ref> <ref>PMID:23178883</ref> <ref>PMID:24332854</ref> <ref>PMID:24560927</ref>
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==See Also==
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*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Jiang Y]]
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[[Category: Wang Y]]

Current revision

MCU holocomplex in Low-calcium blocking state

PDB ID 6xjx

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