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| | <StructureSection load='5wdd' size='340' side='right'caption='[[5wdd]], [[Resolution|resolution]] 1.80Å' scene=''> | | <StructureSection load='5wdd' size='340' side='right'caption='[[5wdd]], [[Resolution|resolution]] 1.80Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5wdd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WDD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WDD FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5wdd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WDD FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.799Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BOK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wdd OCA], [http://pdbe.org/5wdd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wdd RCSB], [http://www.ebi.ac.uk/pdbsum/5wdd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wdd ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wdd OCA], [https://pdbe.org/5wdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wdd RCSB], [https://www.ebi.ac.uk/pdbsum/5wdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wdd ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/BOK_CHICK BOK_CHICK]] May play a role in apoptosis.[UniProtKB:O35425] | + | [https://www.uniprot.org/uniprot/BOK_CHICK BOK_CHICK] May play a role in apoptosis.[UniProtKB:O35425] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Chick]] | + | [[Category: Gallus gallus]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Colman, P M]] | + | [[Category: Colman PM]] |
| - | [[Category: Cowan, A D]] | + | [[Category: Cowan AD]] |
| - | [[Category: Czabotar, P E]] | + | [[Category: Czabotar PE]] |
| - | [[Category: Apoptosis]]
| + | |
| - | [[Category: Bcl-2]]
| + | |
| - | [[Category: Cell death]]
| + | |
| - | [[Category: Pro-apoptotic]]
| + | |
| Structural highlights
Function
BOK_CHICK May play a role in apoptosis.[UniProtKB:O35425]
Publication Abstract from PubMed
Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been fully explored in mammals. Our structural analysis of BOK suggests close resemblance to BAX and BAK structures. Notably, Bok(-/-)Bax(-/-)Bak(-/-) animals exhibited more severe defects and died earlier than Bax(-/-)Bak(-/-) mice, implying that BOK has overlapping roles with BAX and BAK during developmental cell death. By analyzing Bok(-/-)Bax(-/-)Bak(-/-) triple-knockout mice whose cells are incapable of undergoing intrinsic apoptosis, we identified tissues that formed well without this process. We provide evidence that necroptosis, pyroptosis, or autophagy does not substantially substitute for the loss of apoptosis. Albeit very rare, unexpected attainment of adult Bok(-/-)Bax(-/-)Bak(-/-) mice suggests that morphogenesis can proceed entirely without apoptosis mediated by these proteins and possibly without cell death in general.
Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.,Ke FFS, Vanyai HK, Cowan AD, Delbridge ARD, Whitehead L, Grabow S, Czabotar PE, Voss AK, Strasser A Cell. 2018 May 17;173(5):1217-1230.e17. doi: 10.1016/j.cell.2018.04.036. PMID:29775594[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Ke FFS, Vanyai HK, Cowan AD, Delbridge ARD, Whitehead L, Grabow S, Czabotar PE, Voss AK, Strasser A. Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. 2018 May 17;173(5):1217-1230.e17. doi: 10.1016/j.cell.2018.04.036. PMID:29775594 doi:http://dx.doi.org/10.1016/j.cell.2018.04.036
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