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1cks

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{{STRUCTURE_1cks| PDB=1cks | SCENE= }}
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'''HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL'''
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===HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL===
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==Overview==
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The cell cycle regulatory protein CksHs2 binds to the catalytic subunit of the cyclin-dependent kinases (Cdk's) and is essential for their biological function. The crystal structure of the protein was determined at 2.1 A resolution. The CksHs2 structure is an unexpected hexamer formed by the symmetric assembly of three interlocked dimers into an unusual 12-stranded beta barrel fold that may represent a prototype for this class of protein structures. Sequence-conserved regions form the unusual beta strand exchange between the subunits of the dimer, and the metal and anion binding sites associated with the hexamer assembly. The two other sequence-conserved regions line a 12 A diameter tunnel through the beta barrel and form the six exposed, charged helix pairs. Six kinase subunits can be modeled to bind the assembled hexamer without collision, and therefore this CksHs2 hexamer may participate in cell cycle control by acting as the hub for Cdk multimerization in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 8211159 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8211159}}
==About this Structure==
==About this Structure==
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[[Category: Tainer, J A.]]
[[Category: Tainer, J A.]]
[[Category: Cell division]]
[[Category: Cell division]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:50:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:53:05 2008''

Revision as of 17:53, 30 June 2008

Image:1cks.png

Template:STRUCTURE 1cks

HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL

Template:ABSTRACT PUBMED 8211159

About this Structure

1CKS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control., Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA, Science. 1993 Oct 15;262(5132):387-95. PMID:8211159

Page seeded by OCA on Mon Jun 30 20:53:05 2008

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