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7jtl
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/NS8_SARS2 NS8_SARS2]] May play a role in host-virus interaction. | [[http://www.uniprot.org/uniprot/NS8_SARS2 NS8_SARS2]] May play a role in host-virus interaction. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The molecular basis for the severity and rapid spread of the COVID-19 disease caused by SARS-CoV-2 is largely unknown. ORF8 is a rapidly evolving accessory protein that has been proposed to interfere with immune responses. The crystal structure of SARS-CoV-2 ORF8 was determined at 2.04 A resolution by x-ray crystallography. The structure reveals a ~60 residue core similar to SARS-CoV ORF7a with the addition of two dimerization interfaces unique to SARS-CoV-2 ORF8. A covalent disulfide-linked dimer is formed through an N-terminal sequence specific to SARS-CoV-2, while a separate non-covalent interface is formed by another SARS-CoV-2-specific sequence, 73 YIDI 76 . Together the presence of these interfaces shows how SARS-CoV-2 ORF8 can form unique large-scale assemblies not possible for SARS-CoV, potentially mediating unique immune suppression and evasion activities. | ||
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| + | Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion.,Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH bioRxiv. 2020 Aug 27. doi: 10.1101/2020.08.27.270637. PMID:32869027<ref>PMID:32869027</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7jtl" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Structure of SARS-CoV-2 ORF8 accessory protein
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