1cly

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[[Image:1cly.gif|left|200px]]
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{{Seed}}
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[[Image:1cly.png|left|200px]]
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{{STRUCTURE_1cly| PDB=1cly | SCENE= }}
{{STRUCTURE_1cly| PDB=1cly | SCENE= }}
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'''IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER'''
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===IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER===
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==Overview==
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The crystal structures of the murine BR96 Fab and its human chimera have been determined in complex with the nonoate methyl ester derivative of Lewis Y (nLey) at 2.8 A and 2.5 A resolution, respectively. BR96 binds the carbohydrate in a large pocket which is formed by residues of all CDR loops except L2. The binding of the carbohydrate is mediated predominantly by aromatic residues in BR96. Analysis of the structure suggests that BR96 is capable of recognizing a structure larger than the Le(y) tetrasaccharide, providing a possible explanation for its high tumour selectivity. The structure provides a rationale for mutagenesis experiments that have resulted in BR96 CDR loop mutants with increased affinity for nLey and/or tumour cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_7664109}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7664109 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664109}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin c region]]
[[Category: Immunoglobulin c region]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:52:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:55:58 2008''

Revision as of 17:56, 30 June 2008

Image:1cly.png

Template:STRUCTURE 1cly

IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER

Template:ABSTRACT PUBMED 7664109

About this Structure

Full crystallographic information is available from OCA.

Reference

The x-ray structure of an anti-tumour antibody in complex with antigen., Jeffrey PD, Bajorath J, Chang CY, Yelton D, Hellstrom I, Hellstrom KE, Sheriff S, Nat Struct Biol. 1995 Jun;2(6):466-71. PMID:7664109

Page seeded by OCA on Mon Jun 30 20:55:58 2008

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