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1cm8

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{{STRUCTURE_1cm8| PDB=1cm8 | SCENE= }}
{{STRUCTURE_1cm8| PDB=1cm8 | SCENE= }}
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'''PHOSPHORYLATED MAP KINASE P38-GAMMA'''
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===PHOSPHORYLATED MAP KINASE P38-GAMMA===
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==Overview==
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BACKGROUND: Mitogen-activated protein (MAP) kinases mediate the cellular response to stimuli such as pro-inflammatory cytokines and environmental stress. P38gamma is a new member of the MAP kinase family, and is expressed at its highest levels in skeletal muscle. P38gamma is 63% identical in sequence to P38alpha. The structure of P38alpha MAP kinase has been determined in the apo, unphosphorylated, inactive form. The structures of apo unphosphorylated ERK2, a related MAP kinase, and apo phosphorylated ERK2 have also been determined. RESULTS: We have determined the structure of doubly phosphorylated P38gamma in complex with an ATP analog by X-ray crystallography. This is the first report of a structure of an activated kinase in the P38 subfamily, and the first bound to a nucleotide. P38gamma residue phosphoryl-Thr183 forms hydrogen bonds with five basic amino acids, and these interactions induce an interdomain rotation. The conformation of the activation loop of P38gamma is almost identical to that observed in the structure of activated ERK2. However, unlike ERK2, the crystal structure and solution studies indicate that activated P38gamma exists as a monomer. CONCLUSIONS: Interactions mediated by phosphoryl-Thr183 induce structural changes that direct the domains and active-site residues of P38gamma into a conformation consistent with catalytic activity. The conformation of the phosphorylation loop is likely to be similar in all activated MAP kinases, but not all activated MAP kinases form dimers.
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(as it appears on PubMed at http://www.pubmed.gov), where 10508788 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10508788}}
==About this Structure==
==About this Structure==
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[[Category: P38-gamma]]
[[Category: P38-gamma]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:53:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:56:36 2008''

Revision as of 17:56, 30 June 2008

Image:1cm8.png

Template:STRUCTURE 1cm8

PHOSPHORYLATED MAP KINASE P38-GAMMA

Template:ABSTRACT PUBMED 10508788

About this Structure

1CM8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation., Bellon S, Fitzgibbon MJ, Fox T, Hsiao HM, Wilson KP, Structure. 1999 Sep 15;7(9):1057-65. PMID:10508788

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