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6z32

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<StructureSection load='6z32' size='340' side='right'caption='[[6z32]], [[Resolution|resolution]] 3.47&Aring;' scene=''>
<StructureSection load='6z32' size='340' side='right'caption='[[6z32]], [[Resolution|resolution]] 3.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6z32]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z32 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z32 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6z32]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z32 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.47&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGF2R, MPRI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z32 OCA], [http://pdbe.org/6z32 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z32 RCSB], [http://www.ebi.ac.uk/pdbsum/6z32 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z32 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z32 OCA], [https://pdbe.org/6z32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z32 RCSB], [https://www.ebi.ac.uk/pdbsum/6z32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z32 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN]] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
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[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Berger, I]]
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[[Category: Berger I]]
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[[Category: Bochel, A J]]
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[[Category: Bochel AJ]]
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[[Category: Crump, M P]]
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[[Category: Crump MP]]
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[[Category: Harlos, K]]
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[[Category: Harlos K]]
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[[Category: Hassan, B]]
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[[Category: Hassan B]]
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[[Category: Hoppe, H]]
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[[Category: Hoppe H]]
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[[Category: Jones, Y E]]
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[[Category: Jones YE]]
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[[Category: McCoy, A J]]
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[[Category: McCoy AJ]]
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[[Category: Nicholls, R D]]
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[[Category: Nicholls RD]]
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[[Category: Williams, C]]
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[[Category: Williams C]]
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[[Category: Winter, A J]]
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[[Category: Winter AJ]]
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[[Category: Cation-independent mannose 6-phosphate receptor]]
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[[Category: Insulin-like growth factor 2 receptor]]
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[[Category: Mannose 6-phosphate]]
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[[Category: Sugar binding protein]]
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Revision as of 13:40, 24 January 2024

Human cation-independent mannose 6-phosphate/IGF2 receptor domains 7-11

PDB ID 6z32

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