3hkk

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Current revision (15:50, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3hkk' size='340' side='right'caption='[[3hkk]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='3hkk' size='340' side='right'caption='[[3hkk]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3HKK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uuh|2uuh]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkk OCA], [https://pdbe.org/3hkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hkk RCSB], [https://www.ebi.ac.uk/pdbsum/3hkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3hkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hkk OCA], [http://pdbe.org/3hkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hkk RCSB], [http://www.ebi.ac.uk/pdbsum/3hkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hkk ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Haeggstrom, J Z]]
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[[Category: Haeggstrom JZ]]
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[[Category: Rinaldo-Matthis, A]]
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[[Category: Rinaldo-Matthis A]]
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[[Category: Leukotriene biosynthesis]]
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[[Category: Leukotriene c4 synthase]]
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[[Category: Lyase]]
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[[Category: Membrane]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Transmembrane]]
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Current revision

Structure of human Leukotriene C4 synthase in complex with glutathione sulfonate

PDB ID 3hkk

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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