3hz1

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Current revision (08:27, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3hz1' size='340' side='right'caption='[[3hz1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3hz1' size='340' side='right'caption='[[3hz1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hz1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3HZ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HZ1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37D:METHYL+5-FURAN-2-YL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE'>37D</scene>, <scene name='pdbligand=42C:N,N-DIMETHYL-7H-PURIN-6-AMINE'>42C</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hyy|3hyy]], [[3hyz|3hyz]], [[3hz5|3hz5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37D:METHYL+5-FURAN-2-YL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE'>37D</scene>, <scene name='pdbligand=42C:N,N-DIMETHYL-7H-PURIN-6-AMINE'>42C</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3hz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hz1 OCA], [http://pdbe.org/3hz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hz1 RCSB], [http://www.ebi.ac.uk/pdbsum/3hz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hz1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hz1 OCA], [https://pdbe.org/3hz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hz1 RCSB], [https://www.ebi.ac.uk/pdbsum/3hz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hz1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Barker, J]]
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[[Category: Barker J]]
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[[Category: Cheng, R K.Y]]
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[[Category: Cheng RKY]]
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[[Category: Felicetti, B]]
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[[Category: Felicetti B]]
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[[Category: Mather, O]]
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[[Category: Mather O]]
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[[Category: Palan, S]]
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[[Category: Palan S]]
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[[Category: Whittaker, M]]
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[[Category: Whittaker M]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Nucleotide binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Stress response]]
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Current revision

Crystal structure of Hsp90 with fragments 37-D04 and 42-C03

PDB ID 3hz1

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