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5suq

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Current revision (12:48, 4 October 2023) (edit) (undo)
 
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==Structure of mRNA export factors==
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==Crystal structure of the THO-Sub2 complex==
<StructureSection load='5suq' size='340' side='right'caption='[[5suq]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
<StructureSection load='5suq' size='340' side='right'caption='[[5suq]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5suq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SUQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5SUQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5suq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SUQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SUB2, YDL084W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5suq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5suq OCA], [https://pdbe.org/5suq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5suq RCSB], [https://www.ebi.ac.uk/pdbsum/5suq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5suq ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5suq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5suq OCA], [http://pdbe.org/5suq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5suq RCSB], [http://www.ebi.ac.uk/pdbsum/5suq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5suq ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SUB2_YEAST SUB2_YEAST]] ATP-binding RNA helicase component of the TREX complex involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.<ref>PMID:10077188</ref> <ref>PMID:11156602</ref> <ref>PMID:11156603</ref> <ref>PMID:11156604</ref> <ref>PMID:11463828</ref> <ref>PMID:11675790</ref> <ref>PMID:11696331</ref> <ref>PMID:11979277</ref> <ref>PMID:12034490</ref> <ref>PMID:12093753</ref> <ref>PMID:12417727</ref> <ref>PMID:12871933</ref> <ref>PMID:15942929</ref>
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[https://www.uniprot.org/uniprot/SUB2_YEAST SUB2_YEAST] ATP-binding RNA helicase component of the TREX complex involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.<ref>PMID:10077188</ref> <ref>PMID:11156602</ref> <ref>PMID:11156603</ref> <ref>PMID:11156604</ref> <ref>PMID:11463828</ref> <ref>PMID:11675790</ref> <ref>PMID:11696331</ref> <ref>PMID:11979277</ref> <ref>PMID:12034490</ref> <ref>PMID:12093753</ref> <ref>PMID:12417727</ref> <ref>PMID:12871933</ref> <ref>PMID:15942929</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
 
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[[Category: Baker's yeast]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RNA helicase]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Blobel, G]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Ren, Y]]
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[[Category: Blobel G]]
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[[Category: Hydrolase]]
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[[Category: Ren Y]]
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[[Category: Mrna export]]
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Current revision

Crystal structure of the THO-Sub2 complex

PDB ID 5suq

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