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5sy5

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Current revision (12:50, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5sy5' size='340' side='right'caption='[[5sy5]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5sy5' size='340' side='right'caption='[[5sy5]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5sy5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5SY5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5sy5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SY5 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Arnt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Npas1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.201&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5sy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy5 OCA], [http://pdbe.org/5sy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sy5 RCSB], [http://www.ebi.ac.uk/pdbsum/5sy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy5 OCA], [https://pdbe.org/5sy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sy5 RCSB], [https://www.ebi.ac.uk/pdbsum/5sy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). [[http://www.uniprot.org/uniprot/NPAS1_MOUSE NPAS1_MOUSE]] May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.<ref>PMID:15347806</ref> <ref>PMID:15635607</ref>
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[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5sy5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5sy5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Kim, Y]]
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[[Category: Kim Y]]
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[[Category: Potluri, N]]
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[[Category: Potluri N]]
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[[Category: Rastinejad, F]]
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[[Category: Rastinejad F]]
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[[Category: Su, X]]
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[[Category: Su X]]
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[[Category: Wu, D]]
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[[Category: Wu D]]
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[[Category: Bhlh-pas protein]]
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[[Category: Heterodimeric complex]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

Crystal Structure of the Heterodimeric NPAS1-ARNT Complex

PDB ID 5sy5

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