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Sandbox GGC3
From Proteopedia
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== Function == | == Function == | ||
| - | + | SARS-Cov-2 utilizes the S-protein to facilitate attachment to host cell surface membranes. | |
== Disease == | == Disease == | ||
This protein is related to the SARS-cov-2 | This protein is related to the SARS-cov-2 | ||
== Relevance == | == Relevance == | ||
| - | + | The S-protein of SARS-CoV-2 expressed by the ORF1b gene is trimeric in structure, where each monomer is 180 kDa in size and has two main subunits, an S1 and an S2 subunit. S1 subunit attaches itself to the host cell angiotensin-converting enzyme 2 (ACE2) transmembrane protein. S2 subunit acts in the fusion process of the S-protein which is done by the cleavage protease transmembrane serine or furin. | |
== Structural highlights == | == Structural highlights == | ||
Revision as of 14:50, 2 November 2020
Spike glycoprotein
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
