This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Phosphoinositide 3-kinase 3D structures
From Proteopedia
(Difference between revisions)
| Line 23: | Line 23: | ||
**[[3mtt]], [[3o5z]] – hPI3KI p85β <br /> | **[[3mtt]], [[3o5z]] – hPI3KI p85β <br /> | ||
**[[2kt1]] - hPI3KI p85β SH3 domain<br /> | **[[2kt1]] - hPI3KI p85β SH3 domain<br /> | ||
| - | **[[3l4q]] – | + | **[[6ox7]], [[6u28]] – hPI3KI p85β + influenza NS1 protein <br /> |
| + | **[[3l4q]] – bPI3KI p85β + influenza NS1 protein <br /> | ||
*'''Class II''' | *'''Class II''' | ||
| Line 46: | Line 47: | ||
**[[3hiz]], [[4jps]] - hTI-PI3K p110α (mutant) + p85α <br /> | **[[3hiz]], [[4jps]] - hTI-PI3K p110α (mutant) + p85α <br /> | ||
**[[2rd0]], [[4l1b]], [[6nct]] - hTI-PI3K p110α + p85α<br /> | **[[2rd0]], [[4l1b]], [[6nct]] - hTI-PI3K p110α + p85α<br /> | ||
| + | **[[7myn]] - hTI-PI3K p110α + p85α – Cryo EM<br /> | ||
**[[5sxk]], [[5sx8]], [[5sx9]], [[5sxa]], [[5sxb]], [[5sxc]], [[5sxd]], [[5sxe]], [[5sxf]], [[5sxi]], [[5sxj]], [[5sw8]], [[5swg]], [[5swo]], [[5swp]], [[5swr]], [[5swt]], [[5dxh]], [[5xgj]], [[5xgi]]], [[5xgh]] - hTI-PI3K p110α + p85α + inhibitor<br /> | **[[5sxk]], [[5sx8]], [[5sx9]], [[5sxa]], [[5sxb]], [[5sxc]], [[5sxd]], [[5sxe]], [[5sxf]], [[5sxi]], [[5sxj]], [[5sw8]], [[5swg]], [[5swo]], [[5swp]], [[5swr]], [[5swt]], [[5dxh]], [[5xgj]], [[5xgi]]], [[5xgh]] - hTI-PI3K p110α + p85α + inhibitor<br /> | ||
**[[5ul1]], [[5ukj]], [[5itd]], [[5fi4]], [[4zop]] - hTI-PI3K p110α (mutant) + p85α + inhibitor<br /> | **[[5ul1]], [[5ukj]], [[5itd]], [[5fi4]], [[4zop]] - hTI-PI3K p110α (mutant) + p85α + inhibitor<br /> | ||
**[[5uk8]] - hTI-PI3K p110α (mutant) + p85α (mutant) + inhibitor<br /> | **[[5uk8]] - hTI-PI3K p110α (mutant) + p85α (mutant) + inhibitor<br /> | ||
| + | **[[7myo]] - hTI-PI3K p110α + p85α + inhibitor – Cryo EM<br /> | ||
**[[4ovu]] - hTI-PI3K p110α + p85α SH2 domain<br /> | **[[4ovu]] - hTI-PI3K p110α + p85α SH2 domain<br /> | ||
**[[4ovv]] - hTI-PI3K p110α + p85α SH2 domain + phosphatidylinositol-4,5-bisphosphate <br /> | **[[4ovv]] - hTI-PI3K p110α + p85α SH2 domain + phosphatidylinositol-4,5-bisphosphate <br /> | ||
| Line 59: | Line 62: | ||
**[[4tuu]], [[4tv3]] - hTI-PI3K p110α<br /> | **[[4tuu]], [[4tv3]] - hTI-PI3K p110α<br /> | ||
**[[2enq]] - hTI-PI3K p110α C2 domain<br /> | **[[2enq]] - hTI-PI3K p110α C2 domain<br /> | ||
| - | **[[3zim]], [[4a55]], [[4oys]], [[4ph4]], [[4uwf]], [[4uwg]], [[4uwh]], [[4uwk]], [[4uwl]], [[5ubr]], [[5dxt]], [[4ykn]], [[6pys]], [[6oac]], [[6gvi]], [[6gvh]], [[6gvg]], [[6gvf]] - hTI-PI3K p110α + inhibitor<br /> | + | **[[6vo7]] - hTI-PI3K p110α RBD<br /> |
| + | **[[3zim]], [[4a55]], [[4oys]], [[4ph4]], [[4uwf]], [[4uwg]], [[4uwh]], [[4uwk]], [[4uwl]], [[5ubr]], [[5dxt]], [[4ykn]], [[6pys]], [[6oac]], [[6gvi]], [[6gvh]], [[6gvg]], [[6gvf]], [[7k6m]], [[7k6n]], [[7k6o]], [[7k71]] - hTI-PI3K p110α + inhibitor<br /> | ||
| + | **[[7cio]] - hTI-PI3K p110α C2 domain + CTLA-4<br /> | ||
*Type I PI3K p110β | *Type I PI3K p110β | ||
| Line 72: | Line 77: | ||
**[[3l08]] – hTI-PI3K p110γ + GSK2126458 <br /> | **[[3l08]] – hTI-PI3K p110γ + GSK2126458 <br /> | ||
**[[3ibe]]– hTI-PI3K p110γ + pyrazolopyrimidine <br /> | **[[3ibe]]– hTI-PI3K p110γ + pyrazolopyrimidine <br /> | ||
| - | **[[3ene]], [[2v4l]], [[2a4z]], [[2a5u]], [[1e7u]], [[1e7v]], [[1e8w]], [[1e8y]], [[1e8z]], [[1e90]], [[1e8x]], [[3tls]], [[3apc]], [[3apd]], [[3apf]], [[3s2a]], [[3r7q]], [[3r7r]], [[3p2b]], [[3mjw]], [[3nzs]], [[3nzu]], [[3qaq]], [[3qar]], [[3zvv]], [[3zw3]], [[3sd5]], [[3t8m]], [[3tl5]], [[4anu]], [[4anv]], [[4anw]], [[4anx]], [[4aof]], [[4dk5]], [[4f1s]], [[4fa6]], [[4fad]], [[4fhj]], [[4fhk]], [[4fjy]], [[4fjz]], [[4flh]], [[4ful]], [[4g11]], [[4gb9]], [[4hle]], [[4hvb]], [[4j6i]], [[4ps3]], [[4ps7]], [[4ps8]], [[4urk]], [[4wwn]], [[4wwo]], [[4wwp]], [[5t23]], [[5kae]], [[5jhb]], [[5jha]], [[5g55]], [[5g2n]], [[5eds]], [[4xz4]], [[4xx5]], [[6gq7]], [[6fh5]], [[6t3b]], [[6t3c]], [[6xrl]], [[6xrm]] – hTI-PI3K p110γ + inhibitor <br /> | + | **[[3ene]], [[2v4l]], [[2a4z]], [[2a5u]], [[1e7u]], [[1e7v]], [[1e8w]], [[1e8y]], [[1e8z]], [[1e90]], [[1e8x]], [[3tls]], [[3apc]], [[3apd]], [[3apf]], [[3s2a]], [[3r7q]], [[3r7r]], [[3p2b]], [[3mjw]], [[3nzs]], [[3nzu]], [[3qaq]], [[3qar]], [[3zvv]], [[3zw3]], [[3sd5]], [[3t8m]], [[3tl5]], [[4anu]], [[4anv]], [[4anw]], [[4anx]], [[4aof]], [[4dk5]], [[4f1s]], [[4fa6]], [[4fad]], [[4fhj]], [[4fhk]], [[4fjy]], [[4fjz]], [[4flh]], [[4ful]], [[4g11]], [[4gb9]], [[4hle]], [[4hvb]], [[4j6i]], [[4ps3]], [[4ps7]], [[4ps8]], [[4urk]], [[4wwn]], [[4wwo]], [[4wwp]], [[5t23]], [[5kae]], [[5jhb]], [[5jha]], [[5g55]], [[5g2n]], [[5eds]], [[4xz4]], [[4xx5]], [[6gq7]], [[6fh5]], [[6q6y]], [[6q73]], [[6q74]], [[6t3b]], [[6t3c]], [[6xrl]], [[6xrm]] – hTI-PI3K p110γ + inhibitor <br /> |
| - | **[[3tjp]], [[4ezj]], [[4ezk]], [[4ezl]], [[4kz0]], [[4kzc]] - hTI-PI3K p110γ (mutant) + inhibitor<br /> | + | **[[3tjp]], [[4ezj]], [[4ezk]], [[4ezl]], [[4kz0]], [[4kzc]], [[6xrn]], [[6ykg]], [[7jx0]], [[7kke]], [[7jwz]], [[7rsj]], [[7rsp]], [[7rsv]] - hTI-PI3K p110γ (mutant) + inhibitor<br /> |
| + | **[[7jwe]] – hTI-PI3K p110γ + drug<br /> | ||
**[[3dpd]], [[6aud]] – hTI-PI3K p110γ + oxazines inhibitor <br /> | **[[3dpd]], [[6aud]] – hTI-PI3K p110γ + oxazines inhibitor <br /> | ||
**[[3dbs]] – hTI-PI3K p110γ + GDC0941 <br /> | **[[3dbs]] – hTI-PI3K p110γ + GDC0941 <br /> | ||
| Line 80: | Line 86: | ||
**[[3oaw]], [[3ml9]], [[3ml8]], [[3l17]], [[3l16]], [[3l13]], [[3pre]], [[3prz]], [[3ps6]], [[3qjz]], [[3qk0]] – hTI-PI3K p110γ + PI3K/mTOR dual inhibitor<br /> | **[[3oaw]], [[3ml9]], [[3ml8]], [[3l17]], [[3l16]], [[3l13]], [[3pre]], [[3prz]], [[3ps6]], [[3qjz]], [[3qk0]] – hTI-PI3K p110γ + PI3K/mTOR dual inhibitor<br /> | ||
**[[1he8]] - hTI-PI3K p110γ + transforming protein P21/H-RAS-1 effector domain<br /> | **[[1he8]] - hTI-PI3K p110γ + transforming protein P21/H-RAS-1 effector domain<br /> | ||
| + | **[[7mez]] - hTI-PI3K p110 + p101 – cryo EM<br /> | ||
*Type I PI3K p110δ | *Type I PI3K p110δ | ||
**[[2x38]] – hTI-PI3K p110δ + IC87114 <br /> | **[[2x38]] – hTI-PI3K p110δ + IC87114 <br /> | ||
| - | **[[2wxf]], [[2wxg]], [[2wxh]], [[2wxi]], [[2wxj]], [[2wxk]], [[2wxl]], [[2wxm]], [[2wxn]], [[2wxo]], [[2wxp]], [[2wxq]], [[2wxr]], [[4ajw]] – hTI-PI3K p110δ + inhibitor<br /> | + | **[[2wxf]], [[2wxg]], [[2wxh]], [[2wxi]], [[2wxj]], [[2wxk]], [[2wxl]], [[2wxm]], [[2wxn]], [[2wxo]], [[2wxp]], [[2wxq]], [[2wxr]], [[4ajw]], [[6g6w]], [[6pyr]], [[6pyu]], [[6oco]], [[6ocu]], [[7jis]], [[7jiu]], [[7lm2]] – hTI-PI3K p110δ + inhibitor<br /> |
| + | **[[6dgt]], [[6eyz]], [[6ez6]], [[6ftn]], [[6gy0]], [[6hi1]], [[6hi2]], [[6hi9]], [[6mul]], [[6mum]], [[6tnr]], [[6tns]], [[6zaa]], [[6zac]], [[6zad]], [[7oi4]], [[7oij]] [[7oil]], [[7ois]] [[7pop]], [[7por]], [[7pos]], [[7pot]] – mTI-PI3K p110δ + inhibitor<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:33, 13 December 2021
3D Structures of PI3K
Updated on 13-December-2021
