1rti
From Proteopedia
(New page: 200px<br /> <applet load="1rti" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rti, resolution 3.0Å" /> '''HIGH RESOLUTION STRU...) |
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caption="1rti, resolution 3.0Å" /> | caption="1rti, resolution 3.0Å" /> | ||
'''HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES'''<br /> | '''HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RTI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with CYA and HEF as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http:// | + | 1RTI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=CYA:'>CYA</scene> and <scene name='pdbligand=HEF:'>HEF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: hiv-1 reverse transcriptase]] | [[Category: hiv-1 reverse transcriptase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:49:59 2008'' |
Revision as of 14:50, 15 February 2008
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HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Overview
We have determined the structures of four complexes of HIV-1 reverse, transcriptase with non-nucleoside inhibitors, three fully refined at high, resolution. The highest resolution structure is of the RT-nevirapine, complex which has an R-factor of 0.186 and a root-mean-square bond length, deviation of 0.015 A for all data to 2.2 A. The structures reveal a common, mode of binding for these chemically diverse compounds. The common, features of binding are largely hydrophobic interactions and arise from, induced shape complementarity achieved by conformational rearrangement of, the enzyme and conformational/configurational rearrangement of the, compounds.
About this Structure
1RTI is a Protein complex structure of sequences from Human immunodeficiency virus 1 with and as ligands. Active as RNA-directed DNA polymerase, with EC number 2.7.7.49 Full crystallographic information is available from OCA.
Reference
High resolution structures of HIV-1 RT from four RT-inhibitor complexes., Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D, et al., Nat Struct Biol. 1995 Apr;2(4):293-302. PMID:7540934
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