3ipy

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Current revision (07:56, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3ipy' size='340' side='right'caption='[[3ipy]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
<StructureSection load='3ipy' size='340' side='right'caption='[[3ipy]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ipy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IPY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ipy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B87:4-(1-BENZOTHIOPHEN-2-YL)-6-[4-(2-OXO-2-PYRROLIDIN-1-YLETHYL)PIPERAZIN-1-YL]PYRIMIDINE'>B87</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ipx|3ipx]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B87:4-(1-BENZOTHIOPHEN-2-YL)-6-[4-(2-OXO-2-PYRROLIDIN-1-YLETHYL)PIPERAZIN-1-YL]PYRIMIDINE'>B87</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipy OCA], [https://pdbe.org/3ipy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipy RCSB], [https://www.ebi.ac.uk/pdbsum/3ipy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ipy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipy OCA], [http://pdbe.org/3ipy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ipy RCSB], [http://www.ebi.ac.uk/pdbsum/3ipy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
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[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deoxycytidine kinase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carson, K G]]
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[[Category: Carson KG]]
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[[Category: Hoffman, I]]
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[[Category: Hoffman I]]
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[[Category: Hunter, M]]
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[[Category: Hunter M]]
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[[Category: Stouch, T R]]
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[[Category: Stouch TR]]
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[[Category: Swanson, R V]]
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[[Category: Swanson RV]]
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[[Category: Tari, L W]]
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[[Category: Tari LW]]
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[[Category: Atp-binding]]
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[[Category: Human deoxycytidine kinase]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

X-Ray structure of Human Deoxycytidine Kinase in complex with an inhibitor

PDB ID 3ipy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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