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1coi

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{{STRUCTURE_1coi| PDB=1coi | SCENE= }}
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'''DESIGNED TRIMERIC COILED COIL-VALD'''
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===DESIGNED TRIMERIC COILED COIL-VALD===
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==Overview==
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The three-dimensional structure of the 29-residue designed coiled coil having the amino acid sequence acetyl-E VEALEKK VAALESK VQALEKK VEALEHG-amide has been determined and refined to a crystallographic R-factor of 21.4% for all data from 10-A to 2.1-A resolution. This molecule is called coil-VaLd because it contains valine in the a heptad positions and leucine in the d heptad positions. In the trigonal crystal, three molecules, related by a crystallographic threefold axis, form a parallel three-helix bundle. The bundles are stacked head-to-tail to form a continuous coiled coil along the c-direction of the crystal. The contacts among the three helices within the coiled coil are mainly hydrophobic: four layers of valine residues alternate with four layers of leucine residues to form the core of the bundle. In contrast, mostly hydrophilic contacts mediate the interaction between trimers: here a total of two direct protein--protein hydrogen bonds are found. Based on the structure, we propose a scheme for designing crystals of peptides containing continuous two-, three-, and four-stranded coiled coils.
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(as it appears on PubMed at http://www.pubmed.gov), where 9007979 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9007979}}
==About this Structure==
==About this Structure==
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[[Category: Coiled coil design]]
[[Category: Coiled coil design]]
[[Category: Protein design]]
[[Category: Protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:56:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:01:27 2008''

Revision as of 18:01, 30 June 2008

Image:1coi.png

Template:STRUCTURE 1coi

DESIGNED TRIMERIC COILED COIL-VALD

Template:ABSTRACT PUBMED 9007979

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies., Ogihara NL, Weiss MS, Degrado WF, Eisenberg D, Protein Sci. 1997 Jan;6(1):80-8. PMID:9007979

Page seeded by OCA on Mon Jun 30 21:01:27 2008

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