1cok

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[[Image:1cok.gif|left|200px]]
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{{STRUCTURE_1cok| PDB=1cok | SCENE= }}
{{STRUCTURE_1cok| PDB=1cok | SCENE= }}
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'''STRUCTURE OF THE C-TERMINAL DOMAIN OF P73'''
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===STRUCTURE OF THE C-TERMINAL DOMAIN OF P73===
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==Overview==
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p73 and p63 are two recently cloned genes with homology to the tumor suppressor p53, whose protein product is a key transcriptional regulator of genes involved in cell cycle arrest and apoptosis. While all three proteins share conserved transcriptional activation, DNA-binding and oligomerization domains, p73 and p63 have an additional conserved C-terminal region. We have determined the three-dimensional solution structure of this conserved C-terminal domain of human p73. The structure reveals a small five-helix bundle with striking similarity to the SAM (sterile alpha motif) domains of two ephrin receptor tyrosine kinases. The SAM domain is a putative protein-protein interaction domain found in a variety of cytoplasmic signaling proteins and has been shown to form both homo- and hetero-oligomers. However, the SAM-like C-terminal domains of p73 and p63 are monomeric and do not interact with one another, suggesting that this domain may interact with additional, as yet uncharacterized proteins in a signaling and/or regulatory role.
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(as it appears on PubMed at http://www.pubmed.gov), where 10449409 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10449409}}
==About this Structure==
==About this Structure==
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1COK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COK OCA].
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1COK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COK OCA].
==Reference==
==Reference==
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[[Category: Gene regulation]]
[[Category: Gene regulation]]
[[Category: P73 sam-like domain]]
[[Category: P73 sam-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:57:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:01:30 2008''

Revision as of 18:01, 30 June 2008

Image:1cok.png

Template:STRUCTURE 1cok

STRUCTURE OF THE C-TERMINAL DOMAIN OF P73

Template:ABSTRACT PUBMED 10449409

About this Structure

1COK is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:10449409

Page seeded by OCA on Mon Jun 30 21:01:30 2008

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