1coo

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[[Image:1coo.gif|left|200px]]
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{{Seed}}
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[[Image:1coo.png|left|200px]]
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{{STRUCTURE_1coo| PDB=1coo | SCENE= }}
{{STRUCTURE_1coo| PDB=1coo | SCENE= }}
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'''THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE ALPHA SUBUNIT'''
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===THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE ALPHA SUBUNIT===
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==Overview==
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The structure of the carboxyl-terminal domain of the Escherichia coli RNA polymerase alpha subunit (alpha CTD), which is regarded as the contact site for transcription activator proteins and for the promoter UP element, was determined by nuclear magnetic resonance spectroscopy. Its compact structure of four helices and two long arms enclosing its hydrophobic core shows a folding topology distinct from those of other DNA-binding proteins. The UP element binding site was found on the surface comprising helix 1, the amino-terminal end of helix 4, and the preceding loop. Mutation experiments indicated that the contact sites for transcription activator proteins are also on the same surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 7491496 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7491496}}
==About this Structure==
==About this Structure==
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1COO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COO OCA].
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1COO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COO OCA].
==Reference==
==Reference==
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[[Category: Yamazaki, T.]]
[[Category: Yamazaki, T.]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:57:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:01:52 2008''

Revision as of 18:01, 30 June 2008

Image:1coo.png

Template:STRUCTURE 1coo

THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE ALPHA SUBUNIT

Template:ABSTRACT PUBMED 7491496

About this Structure

1COO is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the activator contact domain of the RNA polymerase alpha subunit., Jeon YH, Negishi T, Shirakawa M, Yamazaki T, Fujita N, Ishihama A, Kyogoku Y, Science. 1995 Dec 1;270(5241):1495-7. PMID:7491496

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