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5uig

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Current revision (13:27, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5uig' size='340' side='right'caption='[[5uig]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='5uig' size='340' side='right'caption='[[5uig]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uig]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UIG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UIG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8D1:5-AMINO-N-[(2-METHOXYPHENYL)METHYL]-2-(3-METHYLPHENYL)-2H-1,2,3-TRIAZOLE-4-CARBOXIMIDAMIDE'>8D1</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADORA2A, ADORA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8D1:5-AMINO-N-[(2-METHOXYPHENYL)METHYL]-2-(3-METHYLPHENYL)-2H-1,2,3-TRIAZOLE-4-CARBOXIMIDAMIDE'>8D1</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uig OCA], [http://pdbe.org/5uig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uig RCSB], [http://www.ebi.ac.uk/pdbsum/5uig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uig ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uig OCA], [https://pdbe.org/5uig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uig RCSB], [https://www.ebi.ac.uk/pdbsum/5uig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uig ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bachhawat, P]]
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[[Category: Bachhawat P]]
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[[Category: Ceska, T]]
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[[Category: Ceska T]]
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[[Category: Chu, M Ling-Hon]]
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[[Category: Kobilka B]]
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[[Category: Kobilka, B]]
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[[Category: Kobilka TS]]
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[[Category: Kobilka, T S]]
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[[Category: Lebon F]]
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[[Category: Lebon, F]]
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[[Category: Ling-Hon Chu M]]
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[[Category: Sands, Z]]
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[[Category: Sands Z]]
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[[Category: Sun, B]]
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[[Category: Sun B]]
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[[Category: A2a receptor]]
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[[Category: Adenosine]]
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[[Category: Adenosine binding protein]]
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[[Category: Allosteric]]
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[[Category: Gpcr]]
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[[Category: Parkinson's disease]]
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[[Category: Vapor diffusion]]
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Current revision

Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist

PDB ID 5uig

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