1cpo

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{{STRUCTURE_1cpo| PDB=1cpo | SCENE= }}
{{STRUCTURE_1cpo| PDB=1cpo | SCENE= }}
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'''CHLOROPEROXIDASE'''
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===CHLOROPEROXIDASE===
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==Overview==
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BACKGROUND: Chloroperoxidase (CPO) is a versatile heme-containing enzyme that exhibits peroxidase, catalase and cytochrome P450-like activities in addition to catalyzing halogenation reactions. The structure determination of CPO was undertaken to help elucidate those structural features that enable the enzyme to exhibit these multiple activities. RESULTS: Despite functional similarities with other heme enzymes, CPO folds into a novel tertiary structure dominated by eight helical segments. The catalytic base, required to cleave the peroxide O-O bond, is glutamic acid rather than histidine as in other peroxidases. CPO contains a hydrophobic patch above the heme that could be the binding site for substrates that undergo P450-like reactions. The crystal structure also shows extensive glycosylation with both N- and O-linked glycosyl chains. CONCLUSIONS: The proximal side of the heme in CPO resembles cytochrome P450 because a cysteine residue serves as an axial heme ligand, whereas the distal side of the heme is 'peroxidase-like' in that polar residues form the peroxide-binding site. Access to the heme pocket is restricted to the distal face such that small organic substrates can interact with the iron-linked oxygen atom which accounts for the P450-like reactions catalyzed by chloroperoxidase.
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(as it appears on PubMed at http://www.pubmed.gov), where 8747463 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8747463}}
==About this Structure==
==About this Structure==
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[[Category: Hydrogen-peroxide oxidoreductase]]
[[Category: Hydrogen-peroxide oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:58:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:03:59 2008''

Revision as of 18:04, 30 June 2008

Image:1cpo.png

Template:STRUCTURE 1cpo

CHLOROPEROXIDASE

Template:ABSTRACT PUBMED 8747463

About this Structure

1CPO is a Single protein structure of sequence from Leptoxyphium fumago. Full crystallographic information is available from OCA.

Reference

The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid., Sundaramoorthy M, Terner J, Poulos TL, Structure. 1995 Dec 15;3(12):1367-77. PMID:8747463

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