5vbl

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<StructureSection load='5vbl' size='340' side='right'caption='[[5vbl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5vbl' size='340' side='right'caption='[[5vbl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vbl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VBL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pasteurianus"_(winogradsky_1895)_lehmann_and_neumann_1907 "bacillus pasteurianus" (winogradsky 1895) lehmann and neumann 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VBL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=200:4-CHLORO-L-PHENYLALANINE'>200</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=HRG:L-HOMOARGININE'>HRG</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=OIC:OCTAHYDROINDOLE-2-CARBOXYLIC+ACID'>OIC</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=200:4-CHLORO-L-PHENYLALANINE'>200</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=HRG:L-HOMOARGININE'>HRG</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=OIC:OCTAHYDROINDOLE-2-CARBOXYLIC+ACID'>OIC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbl OCA], [http://pdbe.org/5vbl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vbl RCSB], [http://www.ebi.ac.uk/pdbsum/5vbl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbl ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APLNR, AGTRL1, APJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1501 "Bacillus pasteurianus" (Winogradsky 1895) Lehmann and Neumann 1907])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbl OCA], [https://pdbe.org/5vbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vbl RCSB], [https://www.ebi.ac.uk/pdbsum/5vbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/APJ_HUMAN APJ_HUMAN]] Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
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[[https://www.uniprot.org/uniprot/APJ_HUMAN APJ_HUMAN]] Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Gpcr]]
[[Category: Gpcr]]
[[Category: Human apelin receptor complex]]
[[Category: Human apelin receptor complex]]
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[[Category: Isopeptide]]
[[Category: Lcp]]
[[Category: Lcp]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]

Revision as of 03:40, 2 July 2021

Structure of apelin receptor in complex with agonist peptide

PDB ID 5vbl

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