5vic

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:52, 9 October 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5vic' size='340' side='right'caption='[[5vic]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5vic' size='340' side='right'caption='[[5vic]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5vic]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Den1w Den1w] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VIC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VIC FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5vic]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1_Nauru/West_Pac/1974 Dengue virus 1 Nauru/West Pac/1974] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VIC FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vig|5vig]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vic OCA], [http://pdbe.org/5vic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vic RCSB], [http://www.ebi.ac.uk/pdbsum/5vic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vic ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vic OCA], [https://pdbe.org/5vic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vic RCSB], [https://www.ebi.ac.uk/pdbsum/5vic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vic ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/POLG_DEN1W POLG_DEN1W]] Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity). prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase (By similarity). Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter (By similarity). Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).
+
[https://www.uniprot.org/uniprot/S6B291_HUMAN S6B291_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Den1w]]
+
[[Category: Dengue virus 1 Nauru/West Pac/1974]]
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Bjorkman, P J]]
+
[[Category: Bjorkman PJ]]
-
[[Category: Gristick, H B]]
+
[[Category: Gristick HB]]
-
[[Category: Keeffe, J R]]
+
[[Category: Keeffe JR]]
-
[[Category: West, A P]]
+
[[Category: West Jr AP]]
-
[[Category: Antibody]]
+
-
[[Category: Dengue]]
+
-
[[Category: Fab]]
+
-
[[Category: Immune system]]
+
-
[[Category: Neutralizing]]
+
-
[[Category: Recurrent]]
+
-
[[Category: Zika]]
+

Current revision

Crystal structure of anti-Zika antibody Z004 bound to DENV-1 Envelope protein DIII

PDB ID 5vic

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5vic"
Personal tools