5w3g
From Proteopedia
(Difference between revisions)
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==Solution Structure of ETS Transcription Factor PU.1== | ==Solution Structure of ETS Transcription Factor PU.1== | ||
| - | <StructureSection load='5w3g' size='340' side='right'caption='[[5w3g | + | <StructureSection load='5w3g' size='340' side='right'caption='[[5w3g]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5w3g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W3G OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5w3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W3G FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w3g OCA], [https://pdbe.org/5w3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w3g RCSB], [https://www.ebi.ac.uk/pdbsum/5w3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w3g ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.<ref>PMID:8626664</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Lau DKW]] |
| - | [[Category: | + | [[Category: McIntosh LP]] |
| - | [[Category: | + | [[Category: Okon M]] |
| - | + | ||
Current revision
Solution Structure of ETS Transcription Factor PU.1
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