1cq3

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{{STRUCTURE_1cq3| PDB=1cq3 | SCENE= }}
{{STRUCTURE_1cq3| PDB=1cq3 | SCENE= }}
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'''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS'''
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===STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS===
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==Overview==
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Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.
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(as it appears on PubMed at http://www.pubmed.gov), where 10535930 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10535930}}
==About this Structure==
==About this Structure==
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Chemokine]]
[[Category: Chemokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:59:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:05:41 2008''

Revision as of 18:05, 30 June 2008

Image:1cq3.png

Template:STRUCTURE 1cq3

STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS

Template:ABSTRACT PUBMED 10535930

About this Structure

1CQ3 is a Single protein structure of sequence from Cowpox virus. Full crystallographic information is available from OCA.

Reference

Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus., Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:10535930

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