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1svz
From Proteopedia
(New page: 200px<br /> <applet load="1svz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1svz, resolution 1.89Å" /> '''Crystal structure o...) |
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| - | [[Image:1svz.gif|left|200px]]<br /> | + | [[Image:1svz.gif|left|200px]]<br /><applet load="1svz" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1svz" size=" | + | |
caption="1svz, resolution 1.89Å" /> | caption="1svz, resolution 1.89Å" /> | ||
'''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease'''<br /> | '''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the | + | The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed. |
==About this Structure== | ==About this Structure== | ||
| - | 1SVZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1SVZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Bentley, G | + | [[Category: Bentley, G A.]] |
[[Category: Brynda, J.]] | [[Category: Brynda, J.]] | ||
[[Category: Fabry, M.]] | [[Category: Fabry, M.]] | ||
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[[Category: antibody-antigen complex; hiv inhibiting antibody]] | [[Category: antibody-antigen complex; hiv inhibiting antibody]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:05:51 2008'' |
Revision as of 13:05, 21 February 2008
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Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease
Overview
The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed.
About this Structure
1SVZ is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:15721587
Page seeded by OCA on Thu Feb 21 15:05:51 2008
