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1cr6

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{{STRUCTURE_1cr6| PDB=1cr6 | SCENE= }}
{{STRUCTURE_1cr6| PDB=1cr6 | SCENE= }}
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'''CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR'''
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===CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR===
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==Overview==
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The crystal structure of recombinant murine liver cytosolic epoxide hydrolase (EC 3.3.2.3) has been determined at 2.8-A resolution. The binding of a nanomolar affinity inhibitor confirms the active site location in the C-terminal domain; this domain is similar to that of haloalkane dehalogenase and shares the alpha/beta hydrolase fold. A structure-based mechanism is proposed that illuminates the unique chemical strategy for the activation of endogenous and man-made epoxide substrates for hydrolysis and detoxification. Surprisingly, a vestigial active site is found in the N-terminal domain similar to that of another enzyme of halocarbon metabolism, haloacid dehalogenase. Although the vestigial active site does not participate in epoxide hydrolysis, the vestigial domain plays a critical structural role by stabilizing the dimer in a distinctive domain-swapped architecture. Given the genetic and structural relationships among these enzymes of xenobiotic metabolism, a structure-based evolutionary sequence is postulated.
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(as it appears on PubMed at http://www.pubmed.gov), where 10485878 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10485878}}
==About this Structure==
==About this Structure==
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[[Category: Disubstituted urea inhibitor]]
[[Category: Disubstituted urea inhibitor]]
[[Category: Homodimer]]
[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:02:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:11:48 2008''

Revision as of 18:11, 30 June 2008

Image:1cr6.png

Template:STRUCTURE 1cr6

CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR

Template:ABSTRACT PUBMED 10485878

About this Structure

1CR6 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase., Argiriadi MA, Morisseau C, Hammock BD, Christianson DW, Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10637-42. PMID:10485878

Page seeded by OCA on Mon Jun 30 21:11:48 2008

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