6xfm
From Proteopedia
(Difference between revisions)
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==Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of FUS== | ==Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of FUS== | ||
| - | <StructureSection load='6xfm' size='340' side='right'caption='[[6xfm]]' scene=''> | + | <StructureSection load='6xfm' size='340' side='right'caption='[[6xfm]], [[Resolution|resolution]] 2.62Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XFM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XFM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xfm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XFM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XFM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xfm OCA], [http://pdbe.org/6xfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xfm RCSB], [http://www.ebi.ac.uk/pdbsum/6xfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xfm ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FUS, TLS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xfm OCA], [http://pdbe.org/6xfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xfm RCSB], [http://www.ebi.ac.uk/pdbsum/6xfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xfm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Frontotemporal dementia with motor neuron disease;Hereditary essential tremor;Amyotrophic lateral sclerosis;Juvenile amyotrophic lateral sclerosis;Myxofibrosarcoma;Myxoid/round cell liposarcoma. A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3. A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG. The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN]] Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ghosh U]] | + | [[Category: Ghosh, U]] |
| - | [[Category: Kato M]] | + | [[Category: Kato, M]] |
| - | [[Category: Lee M]] | + | [[Category: Lee, M]] |
| - | [[Category: Thurber K]] | + | [[Category: Thurber, K]] |
| - | [[Category: Tycko R]] | + | [[Category: Tycko, R]] |
| + | [[Category: Amyloid fibril]] | ||
| + | [[Category: Low complexity domain]] | ||
| + | [[Category: Protein aggregation]] | ||
| + | [[Category: Protein fibril]] | ||
| + | [[Category: Rna binding protein]] | ||
Revision as of 08:13, 2 December 2020
Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of FUS
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