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1crl

From Proteopedia

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[[Image:1crl.gif|left|200px]]
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{{STRUCTURE_1crl| PDB=1crl | SCENE= }}
{{STRUCTURE_1crl| PDB=1crl | SCENE= }}
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'''INSIGHTS INTO INTERFACIAL ACTIVATION FROM AN 'OPEN' STRUCTURE OF CANDIDA RUGOSA LIPASE'''
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===INSIGHTS INTO INTERFACIAL ACTIVATION FROM AN 'OPEN' STRUCTURE OF CANDIDA RUGOSA LIPASE===
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==Overview==
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The structure of the Candida rugosa lipase determined at 2.06-A resolution reveals a conformation with a solvent-accessible active site. Comparison with the crystal structure of the homologous lipase from Geotrichum candidum, in which the active site is covered by surface loops and is inaccessible from the solvent, shows that the largest structural differences occur in the vicinity of the active site. Three loops in this region differ significantly in conformation, and the interfacial activation of these lipases is likely to be associated with conformational rearrangements of these loops. The "open" structure provides a new image of the substrate binding region and active site access, which is different from that inferred from the structure of the "closed" form of the G. candidum lipase.
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(as it appears on PubMed at http://www.pubmed.gov), where 8509417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8509417}}
==About this Structure==
==About this Structure==
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[[Category: Cygler, M.]]
[[Category: Cygler, M.]]
[[Category: Grochulski, P.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:02:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:13:48 2008''

Revision as of 18:13, 30 June 2008

Image:1crl.png

Template:STRUCTURE 1crl

INSIGHTS INTO INTERFACIAL ACTIVATION FROM AN 'OPEN' STRUCTURE OF CANDIDA RUGOSA LIPASE

Template:ABSTRACT PUBMED 8509417

About this Structure

1CRL is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Insights into interfacial activation from an open structure of Candida rugosa lipase., Grochulski P, Li Y, Schrag JD, Bouthillier F, Smith P, Harrison D, Rubin B, Cygler M, J Biol Chem. 1993 Jun 15;268(17):12843-7. PMID:8509417

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