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3kfy
From Proteopedia
(Difference between revisions)
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<StructureSection load='3kfy' size='340' side='right'caption='[[3kfy]], [[Resolution|resolution]] 2.08Å' scene=''> | <StructureSection load='3kfy' size='340' side='right'caption='[[3kfy]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3kfy]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3kfy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KFY FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=JZM:5-[(4-CHLOROPHENYL)SULFANYL]QUINAZOLINE-2,4-DIAMINE'>JZM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=JZM:5-[(4-CHLOROPHENYL)SULFANYL]QUINAZOLINE-2,4-DIAMINE'>JZM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dhf|1dhf]], [[3k45|3k45]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dhf|1dhf]], [[3k45|3k45]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfy OCA], [https://pdbe.org/3kfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kfy RCSB], [https://www.ebi.ac.uk/pdbsum/3kfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kfy ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
==See Also== | ==See Also== | ||
Revision as of 05:40, 13 July 2022
Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
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Categories: Dihydrofolate reductase | Escherichia coli | Large Structures | Carroll, M J | Collins, E J | Gromova, A V | Lee, A L | Miller, K R | Singleton, S F | Antibiotic resistance | Dynamic | Methotrexate resistance | Nadp | One-carbon metabolism | Oxidoreductase | Small molecule inhibitor | Trimethoprim resistance
