5xbm

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Current revision (07:58, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5xbm' size='340' side='right'caption='[[5xbm]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='5xbm' size='340' side='right'caption='[[5xbm]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xbm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XBM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XBM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xbm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XBM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.501&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCARB2, CD36L2, LIMP2, LIMPII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xbm OCA], [http://pdbe.org/5xbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xbm RCSB], [http://www.ebi.ac.uk/pdbsum/5xbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xbm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xbm OCA], [https://pdbe.org/5xbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xbm RCSB], [https://www.ebi.ac.uk/pdbsum/5xbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xbm ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Unverricht-Lundborg disease;Gaucher disease type 1;Action myoclonus - renal failure syndrome. The disease is caused by mutations affecting the gene represented in this entry. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.
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[https://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN] Unverricht-Lundborg disease;Gaucher disease type 1;Action myoclonus - renal failure syndrome. The disease is caused by mutations affecting the gene represented in this entry. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.<ref>PMID:18022370</ref>
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[https://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN] Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.<ref>PMID:18022370</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5xbm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5xbm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Guo, H]]
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[[Category: Guo H]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Rao, Z]]
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[[Category: Rao Z]]
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[[Category: Wang, N]]
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[[Category: Wang N]]
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[[Category: Wang, X]]
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[[Category: Wang X]]
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[[Category: Yang, P]]
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[[Category: Yang P]]
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[[Category: Yin, X]]
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[[Category: Yin X]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Zhang, L]]
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[[Category: Zhang L]]
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[[Category: Zhang, X]]
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[[Category: Zhang X]]
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[[Category: Immune system-protein binding complex]]
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[[Category: Monoclonal antibody]]
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[[Category: Scarb2]]
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Current revision

Structure of SCARB2-JL2 complex

PDB ID 5xbm

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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