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Mevalonate kinase

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== Structural highlights ==
== Structural highlights ==
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The 3D structure of MK complex with mevalonate shows the enzyme composed of <scene name='86/864102/Cv/2'>2 domains</scene>: The N-terminal and the C-terminal. The mevalonate binds in a deep cleft between the 2 domains forming H-bond interactions with Arg and Tyr residues and several hydrophobic interactions<ref>PMID:17397541</ref>.
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The 3D structure of MK complex with mevalonate shows the enzyme composed of <scene name='86/864102/Cv/2'>2 domains</scene>: The N-terminal and the C-terminal. The mevalonate binds in a <scene name='86/864102/Cv/3'>deep cleft</scene> between the 2 domains forming H-bond interactions with Arg and Tyr residues and several hydrophobic interactions<ref>PMID:17397541</ref>.
==3D structures of mevalonate kinase==
==3D structures of mevalonate kinase==

Revision as of 13:05, 13 October 2020

Mevalonate kinase complex with mevalonate (PDB code 2hfu).

Drag the structure with the mouse to rotate

References

  1. ↑ Buhaescu I, Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications. Clin Biochem. 2007 Jun;40(9-10):575-84. doi: 10.1016/j.clinbiochem.2007.03.016., Epub 2007 Mar 31. PMID:17467679 doi:http://dx.doi.org/10.1016/j.clinbiochem.2007.03.016
  2. ↑ Levy M, Arion A, Berrebi D, Cuisset L, Jeanne-Pasquier C, Bader-Meunier B, Jung C. Severe early-onset colitis revealing mevalonate kinase deficiency. Pediatrics. 2013 Sep;132(3):e779-83. doi: 10.1542/peds.2012-3344. Epub 2013 Aug, 26. PMID:23979089 doi:http://dx.doi.org/10.1542/peds.2012-3344
  3. ↑ Sgraja T, Smith TK, Hunter WN. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. BMC Struct Biol. 2007 Mar 30;7:20. PMID:17397541 doi:10.1186/1472-6807-7-20

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Alexander Berchansky, Michal Harel

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