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1csl

From Proteopedia

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{{Seed}}
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{{STRUCTURE_1csl| PDB=1csl | SCENE= }}
{{STRUCTURE_1csl| PDB=1csl | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE'''
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===CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE===
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==Overview==
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The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 10656783 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10656783}}
==About this Structure==
==About this Structure==
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[[Category: Hiv-1]]
[[Category: Hiv-1]]
[[Category: Rre high affinity site]]
[[Category: Rre high affinity site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:04:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:17:37 2008''

Revision as of 18:17, 30 June 2008

Image:1csl.png

Template:STRUCTURE 1csl

CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE

Template:ABSTRACT PUBMED 10656783

About this Structure

Full crystallographic information is available from OCA.

Reference

The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783

Page seeded by OCA on Mon Jun 30 21:17:37 2008

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