6umc
From Proteopedia
(Difference between revisions)
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==Crystal structure of human GAC in complex with inhibitor UPGL00012== | ==Crystal structure of human GAC in complex with inhibitor UPGL00012== | ||
| - | <StructureSection load='6umc' size='340' side='right'caption='[[6umc]]' scene=''> | + | <StructureSection load='6umc' size='340' side='right'caption='[[6umc]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMC OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6umc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UMC FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U27:2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide'>U27</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6umc OCA], [https://pdbe.org/6umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6umc RCSB], [https://www.ebi.ac.uk/pdbsum/6umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6umc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Glutaminase 3D structures|Glutaminase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cerione RA]] | [[Category: Cerione RA]] | ||
[[Category: Huang Q]] | [[Category: Huang Q]] | ||
Revision as of 07:54, 11 October 2023
Crystal structure of human GAC in complex with inhibitor UPGL00012
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