6y5w
From Proteopedia
(Difference between revisions)
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==Crystal structure of the envelope glycoprotein complex of Andes virus in a near postfusion conformation== | ==Crystal structure of the envelope glycoprotein complex of Andes virus in a near postfusion conformation== | ||
| - | <StructureSection load='6y5w' size='340' side='right'caption='[[6y5w]]' scene=''> | + | <StructureSection load='6y5w' size='340' side='right'caption='[[6y5w]], [[Resolution|resolution]] 2.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y5W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y5W FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6y5w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Andes_hantavirus Andes hantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y5W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y5W FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y5w OCA], [http://pdbe.org/6y5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y5w RCSB], [http://www.ebi.ac.uk/pdbsum/6y5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y5w ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">M, ADT63_73450gpM, ADT63_73451gpM, ADT63_73452gpM, ADT63_74519gpM, ADT63_74520gpM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1980456 Andes hantavirus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y5w OCA], [http://pdbe.org/6y5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y5w RCSB], [http://www.ebi.ac.uk/pdbsum/6y5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y5w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for which no treatment is available. Hantavirus particles are pleomorphic and display a characteristic square surface lattice. The envelope glycoproteins Gn and Gc form heterodimers that further assemble into tetrameric spikes, the lattice building blocks. The glycoproteins, which are the sole targets of neutralizing antibodies, drive virus entry via receptor-mediated endocytosis and endosomal membrane fusion. Here we describe the high-resolution X-ray structures of the heterodimer of Gc and the Gn head and of the homotetrameric Gn base. Docking them into an 11.4-A-resolution cryoelectron tomography map of the hantavirus surface accounted for the complete extramembrane portion of the viral glycoprotein shell and allowed a detailed description of the surface organization of these pleomorphic virions. Our results, which further revealed a built-in mechanism controlling Gc membrane insertion for fusion, pave the way for immunogen design to protect against pathogenic hantaviruses. | ||
| + | |||
| + | The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.,Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P Cell. 2020 Sep 9. pii: S0092-8674(20)31064-3. doi: 10.1016/j.cell.2020.08.023. PMID:32937107<ref>PMID:32937107</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6y5w" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Andes hantavirus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Guardado-Calvo P]] | + | [[Category: Guardado-Calvo, P]] |
| - | [[Category: Rey | + | [[Category: Rey, F A]] |
| - | [[Category: Serris A]] | + | [[Category: Serris, A]] |
| + | [[Category: Class-ii fusion protein hantavirus bunyavirus]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 20:51, 28 October 2020
Crystal structure of the envelope glycoprotein complex of Andes virus in a near postfusion conformation
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