1ctl

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{{STRUCTURE_1ctl| PDB=1ctl | SCENE= }}
{{STRUCTURE_1ctl| PDB=1ctl | SCENE= }}
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'''STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP'''
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===STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP===
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==Overview==
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The three dimensional solution structure of the carboxy terminal LIM domain of the avian Cysteine Rich Protein (CRP) has been determined by nuclear magnetic resonance spectroscopy. The domain contains two zinc atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules. Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules pack due to hydrophobic interactions forming a novel global fold. The structure of the C-terminal CCCC module is essentially identical to that observed for the DNA-interactive CCCC modules of the GATA-1 and steroid hormone receptor DNA binding domains, raising the possibility that the LIM motif may have a DNA binding function.
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(as it appears on PubMed at http://www.pubmed.gov), where 7664053 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664053}}
==About this Structure==
==About this Structure==
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1CTL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA].
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1CTL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTL OCA].
==Reference==
==Reference==
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[[Category: Winge, D R.]]
[[Category: Winge, D R.]]
[[Category: Lim domain containing protein]]
[[Category: Lim domain containing protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:05:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:20:44 2008''

Revision as of 18:20, 30 June 2008

Image:1ctl.png

Template:STRUCTURE 1ctl

STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP

Template:ABSTRACT PUBMED 7664053

About this Structure

1CTL is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP., Perez-Alvarado GC, Miles C, Michelsen JW, Louis HA, Winge DR, Beckerle MC, Summers MF, Nat Struct Biol. 1994 Jun;1(6):388-98. PMID:7664053

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