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7a04

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Current revision (12:01, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7a04' size='340' side='right'caption='[[7a04]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='7a04' size='340' side='right'caption='[[7a04]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7a04]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A04 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7A04 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7a04]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A04 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QTK:1-(phenylmethyl)-4-pyrrolidin-1-yl-pyridin-1-ium'>QTK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHKA, CHK, CKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QTK:1-(phenylmethyl)-4-pyrrolidin-1-yl-pyridin-1-ium'>QTK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7a04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a04 OCA], [http://pdbe.org/7a04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7a04 RCSB], [http://www.ebi.ac.uk/pdbsum/7a04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7a04 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a04 OCA], [https://pdbe.org/7a04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a04 RCSB], [https://www.ebi.ac.uk/pdbsum/7a04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a04 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
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[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7a04" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7a04" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Choline kinase 3D structures|Choline kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ballarotto, M]]
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[[Category: Ballarotto M]]
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[[Category: Carrasco-Jimenez, M P]]
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[[Category: Carrasco-Jimenez MP]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Castro Navas FC]]
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[[Category: Lopez-Cara, L C]]
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[[Category: Hurtado-Guerrero R]]
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[[Category: Macchiarulo, A]]
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[[Category: Lopez-Cara LC]]
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[[Category: Marco, C]]
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[[Category: Macchiarulo A]]
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[[Category: Mariotto, E]]
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[[Category: Marco C]]
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[[Category: Navas, F C.Castro]]
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[[Category: Mariotto E]]
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[[Category: Rubbini, G]]
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[[Category: Rubbini G]]
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[[Category: Serran-Aguilera, L]]
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[[Category: Serran-Aguilera L]]
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[[Category: Viola, G]]
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[[Category: Viola G]]
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[[Category: Anti proliferative effect]]
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[[Category: Cancer]]
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[[Category: Choline kinase]]
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[[Category: Drug]]
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[[Category: Half molecule]]
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[[Category: Transferase]]
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Current revision

Structure of human CKa1 in complex with compound b

PDB ID 7a04

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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