5xht

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==The PHD finger of human Kiaa1045 protein==
==The PHD finger of human Kiaa1045 protein==
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<StructureSection load='5xht' size='340' side='right'caption='[[5xht]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='5xht' size='340' side='right'caption='[[5xht]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xht]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XHT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XHT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xht]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XHT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xht OCA], [http://pdbe.org/5xht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xht RCSB], [http://www.ebi.ac.uk/pdbsum/5xht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xht ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xht OCA], [https://pdbe.org/5xht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xht RCSB], [https://www.ebi.ac.uk/pdbsum/5xht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xht ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/PHF24_HUMAN PHF24_HUMAN]
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Cross-brace structural motifs are required as a scaffold to design artificial RING fingers (ARFs) that function as ubiquitin ligase (E3) in ubiquitination and have specific ubiquitin-conjugating enzyme (E2)-binding capabilities. The Simple Modular Architecture Research Tool database predicted the amino acid sequence 131-190 (KIAA1045ZF) of the human KIAA1045 protein as an unidentified structural region. Herein, the stoichiometry of zinc ions estimated spectrophotometrically by the metallochromic indicator revealed that the KIAA1045ZF motif binds to two zinc atoms. The structure of the KIAA1045ZF motif bound to the zinc atoms was elucidated at the atomic level by nuclear magnetic resonance. The actual structure of the KIAA1045ZF motif adopts a C4 HC3 -type PHD fold belonging to the cross-brace structural family. Therefore, the utilization of the KIAA1045ZF motif as a scaffold may lead to the creation of a novel ARF.
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Solution structure of the PHD finger from the human KIAA1045 protein.,Miyamoto K, Yamashita A, Saito K Protein Sci. 2018 May;27(5):987-992. doi: 10.1002/pro.3389. Epub 2018 Mar 5. PMID:29430827<ref>PMID:29430827</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5xht" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Miyamoto, K]]
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[[Category: Miyamoto K]]
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[[Category: Metal binding protein]]
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[[Category: Phd finger]]
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[[Category: Zinc finger]]
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Current revision

The PHD finger of human Kiaa1045 protein

PDB ID 5xht

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