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Potassium channel 3D structures

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Line 19: Line 19:
**[[4llo]] – mKCh EAG1 <br />
**[[4llo]] – mKCh EAG1 <br />
**[[5u76]], [[5u70]], [[5a6g]], [[5a6f]], [[5a6e]] – cKCh SLO2.2 – chicken – CryoEM<br />
**[[5u76]], [[5u70]], [[5a6g]], [[5a6f]], [[5a6e]] – cKCh SLO2.2 – chicken – CryoEM<br />
 +
**[[7atz]] – AtKCh AKT1 – ''Arabidopsis thaliana'' – Cryo EM<br />
**[[1ho2]], [[1ho7]] - DmKCh L45 segment - ''Drosophila melanogaster'' - NMR<br />
**[[1ho2]], [[1ho7]] - DmKCh L45 segment - ''Drosophila melanogaster'' - NMR<br />
**[[5aar]] – AtKCh AKT1 ankyrin domain – ''Arabidopsis thaliana''<br />
**[[5aar]] – AtKCh AKT1 ankyrin domain – ''Arabidopsis thaliana''<br />
Line 36: Line 37:
**[[6eo1]] - MlotiK1 + K – ''Mesorhizobium loti''<br />
**[[6eo1]] - MlotiK1 + K – ''Mesorhizobium loti''<br />
**[[3co2]], [[1vp6]] - MlotiK1 cyclic nucleotide binding domain - ''Mesorhizobium loti''<br />
**[[3co2]], [[1vp6]] - MlotiK1 cyclic nucleotide binding domain - ''Mesorhizobium loti''<br />
 +
**[[7pxe]], [[7pxf]] – DmKCH – Cryo EM<br />
**[[2kyh]] - AeKCh voltage ensing domain - ''Aeropyrum pernix'' - NMR<br />
**[[2kyh]] - AeKCh voltage ensing domain - ''Aeropyrum pernix'' - NMR<br />
**[[6uwm]] – AeKCH residues 25-295 – Cryo EM<br />
**[[6uwm]] – AeKCH residues 25-295 – Cryo EM<br />
Line 50: Line 52:
**[[1exb]] - rKCh Kv1.1 T1 domain + KV beta2 protein<br />
**[[1exb]] - rKCh Kv1.1 T1 domain + KV beta2 protein<br />
**[[2p7t]] - rKCh + FAV<br />
**[[2p7t]] - rKCh + FAV<br />
-
**[[3lnm]], [[6ebl]], [[6ebk]] - rKCh Kv2.1/KCh Kv1.2 (mutant)<br />
+
**[[3lnm]], [[6ebl]], [[6ebk]], [[6ebm]] - rKCh Kv2.1/KCh Kv1.2 (mutant)<br />
**[[5k7l]] - rKCh EAG1 + calmodulin <br />
**[[5k7l]] - rKCh EAG1 + calmodulin <br />
**[[6pbx]], [[6pby]] - rKCh EAG1 + calmodulin – Cryo EM <br />
**[[6pbx]], [[6pby]] - rKCh EAG1 + calmodulin – Cryo EM <br />
Line 60: Line 62:
**[[3f5w]], [[1zwi]], [[2hjf]] - mKCh (mutant) + antibody heavy+light chains<br />
**[[3f5w]], [[1zwi]], [[2hjf]] - mKCh (mutant) + antibody heavy+light chains<br />
**[[5vms]] - KCh Kv7.1 + calmodulin - frog <br />
**[[5vms]] - KCh Kv7.1 + calmodulin - frog <br />
-
**[[3pjs]], [[5j9p]], [[4uuj]], [[4msw]], [[5vkh]], [[5vke]], [[5vk6]], [[6w0a]], [[6w0b]], [[6w0c]], [[6w0d]], [[6w0e]], [[6w0f]], [[6w0g]], [[6w0h]], [[6w0i]], [[6w0j]] – SlKCh Kcsa pore domain + antibody<br />
+
**[[7pxg]], [[7pxh]] – DmKCH + inhibitor – Cryo EM<br />
 +
**[[3pjs]], [[5j9p]], [[4uuj]], [[4msw]], [[5vkh]], [[5vke]], [[5vk6]], [[6w0a]], [[6w0b]], [[6w0c]], [[6w0d]], [[6w0e]], [[6w0f]], [[6w0g]], [[6w0h]], [[6w0i]], [[6w0j]], [[7m2h]], [[7m2i]], [[7m2j]], [[7rp0]] – SlKCh Kcsa pore domain + antibody<br />
**[[1k4c]], [[1k4d]], [[4lcu]], [[5ec2]], [[5ec1]], [[5ebw]], [[5ebm]], [[5ebl]], [[5e1a]], [[4lbe]], [[6pa0]], [[6nfu]], [[6nfv]] - SlKCh Kcsa pore domain (mutant) + antibody <br />
**[[1k4c]], [[1k4d]], [[4lcu]], [[5ec2]], [[5ec1]], [[5ebw]], [[5ebm]], [[5ebl]], [[5e1a]], [[4lbe]], [[6pa0]], [[6nfu]], [[6nfv]] - SlKCh Kcsa pore domain (mutant) + antibody <br />
**[[2a9h]] - SlKCh Kcsa pore domain (mutant) + charybdotoxin<br />
**[[2a9h]] - SlKCh Kcsa pore domain (mutant) + charybdotoxin<br />
Line 70: Line 73:
*Human potassium Channel
*Human potassium Channel
-
**[[1b4g]], [[1b4i]] - hKCh inactivation domain - human - NMR<br />
+
**[[4hqa]], [[4hp9]] - hKCh ERG PAS domain 1-135 - human<br />
-
**[[1byw]] - hKCh ERG N-terminal (mutant)<br />
+
**[[1byw]] – hKCh ERG PAS domain (mutant)<br />
-
**[[4hqa]], [[4hp9]] - hKCh ERG PAS domain<br />
+
**[[2l1m]], [[2l4r]] – hKCh PAS domain – NMR<br />
-
**[[1ujl]] - hKCh ERG1 extracellular linker - NMR<br />
+
**[[1b4g]], [[1b4l]], [[1ujl]] - hKCh ERG1 extracellular linker 1-42 – NMR<br />
-
**[[2l1m]], [[2l4r]], [[2l0w]] - hKCh HERG - NMR<br />
+
**[[7cn0]], [[7cn1]] – hKCh ERG + K - CryoEM<br />
 +
**[[7ej1]] – hKCh Kv1.3 - CryoEM<br />
 +
**[[7ej2]] – hKCh Kv1.3 (mutant) - CryoEM<br />
 +
**[[6pis]], [[7lj4]], [[7lj5]], [[7lja]], [[7ljb]] – hKCh Kv4.1 (mutant) + antibody<br />
 +
**[[7f0j]] – hKCh Kv4.2 - CryoEM<br />
 +
**[[7e7z]], [[7e83]], [[7e84]], [[7f3f]] – hKCh Kv4.2 + KChlP1 - CryoEM<br />
 +
**[[7e87]], [[7e8b]] – hKCh Kv4.2 + DPP6S - CryoEM<br />
 +
**[[7e86]], [[7e8e]] – hKCh Kv4.2 + KChlP1 + DPP6S - CryoEM<br />
**[[1s1g]] - hKCh Kv4.3 T1 domain<br />
**[[1s1g]] - hKCh Kv4.3 T1 domain<br />
**[[2nz0]] – hKCh Kv4.3 N-terminal+KV channel interacting protein 1 <br />
**[[2nz0]] – hKCh Kv4.3 N-terminal+KV channel interacting protein 1 <br />
Line 80: Line 90:
**[[3bj4]] - hKCh Kv7.1 C-termianl<br />
**[[3bj4]] - hKCh Kv7.1 C-termianl<br />
**[[3hfc]], [[3hfe]] - hKCh Kv7.1 (mutant) <br />
**[[3hfc]], [[3hfe]] - hKCh Kv7.1 (mutant) <br />
 +
**[[6syg]] – hKCh Kv11.1 NBD<br />
**[[5va2]], [[5va1]] – hKCh Kv11.1 - CryoEM<br />
**[[5va2]], [[5va1]] – hKCh Kv11.1 - CryoEM<br />
**[[5va3]] – hKCh Kv11.1 (mutant) - CryoEM<br />
**[[5va3]] – hKCh Kv11.1 (mutant) - CryoEM<br />
Line 89: Line 100:
**[[4umo]] - hKCh Kv7.1 (mutant) + calmodulin <br />
**[[4umo]] - hKCh Kv7.1 (mutant) + calmodulin <br />
**[[5j03]], [[6feh]], [[6feg]] - hKCh Kv7.2 + calmodulin <br />
**[[5j03]], [[6feh]], [[6feg]] - hKCh Kv7.2 + calmodulin <br />
-
**[[6b8p]], [[6b8n]], [[6b8m]], [[6b8l]], [[6n5w]] - hKCh Kv7.4 + calmodulin <br />
 
**[[6b8q]] - hKCh Kv7.5 + calmodulin <br />
**[[6b8q]] - hKCh Kv7.5 + calmodulin <br />
**[[6rv2]] - hKCh TASK-1 <br />
**[[6rv2]] - hKCh TASK-1 <br />
**[[6rv3]], [[6rv4]] - hKCh TASK-1 + inhibitor <br />
**[[6rv3]], [[6rv4]] - hKCh TASK-1 + inhibitor <br />
 +
**[[6uzz]], [[6v00]] – hKCh KCNQ1 + KCNE3 + calmodulin - CryoEM<br />
 +
**[[6v01]] – hKCh KCNQ1 + KCNE3 + calmodulin + PTDINS - CryoEM<br />
 +
**[[7cr0]] – hKCh KCNQ2 - CryoEM<br />
 +
**[[7cr3]] – hKCh KCNQ2 + calmodulin - CryoEM<br />
 +
**[[7cr1]] – hKCh KCNQ2 + pyridine derivative - CryoEM<br />
 +
**[[7cr4]] – hKCh KCNQ2 + pyridine derivative + calmodulin - CryoEM<br />
 +
**[[7cr2]] – hKCh KCNQ2 + drug - CryoEM<br />
 +
**[[7cr7]] – hKCh KCNQ2 + calmodulin + drug - CryoEM<br />
 +
**[[6b8p]], [[6b8n]], [[6b8m]], [[6b8l]], [[6n5w]], [[7byl]] – hKCh KCNQ4 + calmodulin - CryoEM<br />
 +
**[[7bym]], [[7byn]] – hKCh KCNQ4 + calmodulin + drug - CryoEM<br />
*Inward rectifier KCh
*Inward rectifier KCh
-
**[[6c3p]], [[6c3o]] - hIRK 11 + SUR1 + ATP + ADP – Cryo EM<br />
+
**[[7s5t]] - hIRK 11 – Cryo EM<br />
 +
**[[6c3p]], [[6c3o]], [[7s5v]] - hIRK 11 + SUR1 + ATP + ADP – Cryo EM<br />
 +
**[[7s5x]], [[7s5y]], [[7s5z]], [[7s60]], [[7s61]] - hIRK 11 (mutant) + sulfonylurea receptor + ATP + ADP – Cryo EM<br />
**[[6baa]] - hIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
**[[6baa]] - hIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
**[[3ukm]] – hIRK TWIK-1<br />
**[[3ukm]] – hIRK TWIK-1<br />
Line 104: Line 126:
**[[4i9w]] - hIRK TRAAK (mutant) + antibody<br />
**[[4i9w]] - hIRK TRAAK (mutant) + antibody<br />
**[[6pz9]], [[6pza]], [[5twv]] - rIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
**[[6pz9]], [[6pza]], [[5twv]] - rIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
 +
**[[7sk0]], [[7sk1]] - rTWIK1 – Cryo EM<br />
 +
**[[7mit]], [[7mjo]], [[7mjp]], [[7mjq]] – rKATP Kir6.1 + ATP – Cryo EM<br />
**[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br />
**[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br />
**[[2xky]] - mIRK 2 cytoplasmic domain - EM<br />
**[[2xky]] - mIRK 2 cytoplasmic domain - EM<br />
Line 115: Line 139:
**[[3syc]], [[3syp]] - mIRK 3.2 (mutant) <br />
**[[3syc]], [[3syp]] - mIRK 3.2 (mutant) <br />
**[[3sya]] - mIRK 3.2 + PIP2<br />
**[[3sya]] - mIRK 3.2 + PIP2<br />
 +
**[[6xeu]] - mGIRK 2 + PIP2 – Cryo EM<br />
 +
**[[6xev]] - mGIRK 2 + PIP2 + cholesterol derivative – Cryo EM<br />
**[[3syq]] - mIRK 3.2 (mutant) + PIP2<br />
**[[3syq]] - mIRK 3.2 (mutant) + PIP2<br />
**[[4kfm]] - mIRK 3.2 + guanine nucleotide-biding protein<br />
**[[4kfm]] - mIRK 3.2 + guanine nucleotide-biding protein<br />
Line 126: Line 152:
**[[3spg]], [[3sph]], [[5kum]], [[5kuk]], [[6m84]] – cIRK 2.2 (mutant) + PIP2<br />
**[[3spg]], [[3sph]], [[5kum]], [[5kuk]], [[6m84]] – cIRK 2.2 (mutant) + PIP2<br />
**[[3spi]] – cIRK 2.2 + PIP2<br />
**[[3spi]] – cIRK 2.2 + PIP2<br />
-
**[[7cal]] - AtIRK KAT1 – Cryo EM<br />
+
**[[6v1x]], [[6v1y]], [[7cal]] - AtIRK KAT1 – Cryo EM<br />
-
**[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]], [[6o9u]] - MmIRK KIRBAC3.1<br />
+
**[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]], [[6o9u]] - MmIRK KIRBac3.1<br />
-
**[[4lp8]], [[6o9t]], [[6o9v]] - MmIRK KIRBAC3.1 (mutant) <br />
+
**[[4lp8]], [[6o9t]], [[6o9v]], [[7adi]], [[7n9k]], [[7n9l]] - MmIRK KIRBac3.1 (mutant) <br />
**[[3zrs]] – MmIRK 10<br />
**[[3zrs]] – MmIRK 10<br />
**[[1p7b]] - BpIRK C-terminal<br />
**[[1p7b]] - BpIRK C-terminal<br />
Line 137: Line 163:
**[[4bw5]], [[4xdj]] – hKCh TREK-2<br />
**[[4bw5]], [[4xdj]] – hKCh TREK-2<br />
**[[4xdl]], [[4xdk]] – hKCh TREK-2 + Prozac derivative<br />
**[[4xdl]], [[4xdk]] – hKCh TREK-2 + Prozac derivative<br />
-
**[[6cq9]], [[6cq8]], [[6cq6]] – mKCh TREK-1 (mutant)<br />
+
**[[5vkp]], [[5vkn]], [[5vk5]], [[6cq6]], [[6cq8]], [[6cq9]], [[6v36]], [[6v37]], [[6v3c]], [[6v3i]], [[6w7b]], [[6w7c]], [[6w7d]], [[6w7e]], [[6w82]], [[6w83]], [[6w84]], [[6w85]], [[6w86]], [[6w87]], [[6w88]], [[6w8a]], [[6w8c]], [[6w8f]] – mKCh TREK-1 (mutant)<br />
*MthK
*MthK
-
**[[6u5n]], [[6u5p]], [[6u5r]], [[6u68]], [[6u6d]], [[6u6e]], [[6u6h]] - MthK - ''Methanobacterium thermoautrophicum'' – Cryo EM<br />
+
**[[6u5n]], [[6u5p]], [[6u5r]], [[6u68]], [[6u6d]], [[6u6e]], [[6u6h]], [[6u9p]], [[6u9t]], [[6u9y]], [[6u9z]] - MthK - ''Methanobacterium thermoautrophicum'' – Cryo EM<br />
**[[6oly]] - MthK (mutant) <br />
**[[6oly]] - MthK (mutant) <br />
**[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]], [[4ro0]] - MthK RCK domain <br />
**[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]], [[4ro0]] - MthK RCK domain <br />

Revision as of 08:53, 31 January 2022

3D structures of Potassium Channels

Updated on 31-January-2022

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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