Serine/threonine protein kinase 3D structures

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**[[5dh3]] – hChk3 kinase domain + inhibitor<br />
**[[5dh3]] – hChk3 kinase domain + inhibitor<br />
-
*'''Chk4 (Mst1)'''
+
*'''Chk4 (Mst1)''' ); Domains – kinase 1-311; SARAH 432-480
-
**[[2jo8]] – hChk4 C terminal domain - NMR<br />
 
**[[3com]] – hChk4 kinase domain<br />
**[[3com]] – hChk4 kinase domain<br />
 +
**[[6yat]] – hChk4 kinase domain + inhibitor<br />
**[[4nr2]] – hChk4 SARAH domain<br />
**[[4nr2]] – hChk4 SARAH domain<br />
 +
**[[2jo8]] – hChk4 SARAH domain - NMR<br />
**[[4oh8]] – hChk4 SARAH domain + Ras association domain-containing protein<br />
**[[4oh8]] – hChk4 SARAH domain + Ras association domain-containing protein<br />
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**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
**[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
**[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
-
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]] – hChk6 kinase domain + inhibitor<br />
+
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]] – hChk6 kinase domain + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
Line 146: Line 147:
**[[4b6l]], [[4i6b]] – hChk Plk3 kinase domain + inhibitor<br />
**[[4b6l]], [[4i6b]] – hChk Plk3 kinase domain + inhibitor<br />
-
*'''Plk4'''
+
*'''Plk4'''; Domains – kinase 2-275; Pbd 580-808; Pb3 884-970
**[[3cok]] – hChk Plk4 kinase domain<br />
**[[3cok]] – hChk Plk4 kinase domain<br />
**[[4n9j]] – hChk Plk4 Pbd domain<br />
**[[4n9j]] – hChk Plk4 Pbd domain<br />
**[[4n7z]], [[4n7v]] – hChk Plk4 Pbd domain + centrosomal protein <br />
**[[4n7z]], [[4n7v]] – hChk Plk4 Pbd domain + centrosomal protein <br />
 +
**[[6w38]], [[6w3i]] – hChk Plk4 Pbd domain + Fam46C<br />
 +
**[[6w3j]] – hChk Plk4 Pbd domain + Fam46C + CEP92 peptide<br />
**[[4jxf]], [[4yur]] – hChk Plk4 kinase domain + inhibitor<br />
**[[4jxf]], [[4yur]] – hChk Plk4 kinase domain + inhibitor<br />
**[[5lhy]] – hChk Plk4 Pb3 domain<br />
**[[5lhy]] – hChk Plk4 Pb3 domain<br />
Line 160: Line 163:
**[[2buj]] – hChk16 (mutant) + staurosporin <br />
**[[2buj]] – hChk16 (mutant) + staurosporin <br />
-
*'''Chk17'''
+
*'''Chk17B'''
**[[3lm0]] – hChk17B <br />
**[[3lm0]] – hChk17B <br />
**[[6qf4]] – hChk17B + ADP<br />
**[[6qf4]] – hChk17B + ADP<br />
**[[3lm5]] – hChk17B + quercetin<br />
**[[3lm5]] – hChk17B + quercetin<br />
 +
**[[6y6f]], [[6y6h]], [[6zjf]] – hChk17B + pyrimidine derivative<br />
*'''Chk24 (Mst3)'''
*'''Chk24 (Mst3)'''
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*'''Rac-β hChk'''
*'''Rac-β hChk'''
-
**[[1gzk]], [[1gzn]], [[1gzo]], [[1mrv]], [[1mry]] – Rac-β hChk kinase domain<br />
+
**[[1gzk]], [[1gzn]], [[1gzo]], [[1mrv]], [[1mry]] – hRac-β hChk kinase domain<br />
-
**[[1p6s]] - Rac-β hChk pleckstrin homology domain - NMR<br />
+
**[[1p6s]] - hRac-β hChk pleckstrin homology domain - NMR<br />
-
**[[1o6k]] - Rac-β hChk kinase domain + GSK3 peptide + AMPPNP<br />
+
**[[1o6k]] - hRac-β hChk kinase domain + GSK3 peptide + AMPPNP<br />
-
**[[2jdo]], [[2jdr]], [[2uw9]], [[2x39]], [[3cqu]], [[3cqw]] - Rac-β hChk kinase domain + GSK3 peptide + inhibitor<br />
+
**[[2jdo]], [[2jdr]], [[2uw9]], [[2x39]], [[3cqu]], [[3cqw]] - hRac-β hChk kinase domain + GSK3 peptide + inhibitor<br />
**[[3e87]], [[3e88]], [[3e8d]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
**[[3e87]], [[3e88]], [[3e8d]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
-
**[[1o6l]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
+
**[[1o6l]] - hRac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
-
**[[3d0e]] - Rac-β hChk kinase domain (mutant) + inhibitor<br />
+
**[[3d0e]] - hRac-β hChk kinase domain (mutant) + inhibitor<br />
*'''Rac-γ hChk'''
*'''Rac-γ hChk'''
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**[[1uwj]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
**[[1uwj]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br />
**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br />
-
**[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
+
**[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]] - hB-Raf kinase domain + inhibitor<br />
**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]] - hB-Raf kinase domain + inhibitor<br />
 +
**[[6p3d]] – hB-Raf kinase domain (mutant) + cancer drug<br />
**[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
**[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
**[[6u2h]] – hB-Raf kinase domain + 14-3-3 ζ/δ<br />
**[[6u2h]] – hB-Raf kinase domain + 14-3-3 ζ/δ<br />
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**[[6u2g]] – hB-Raf kinase domain + MEK1 + AMPPCP<br />
**[[6u2g]] – hB-Raf kinase domain + MEK1 + AMPPCP<br />
**[[5vr3]] – hB-Raf BRS domain <br />
**[[5vr3]] – hB-Raf BRS domain <br />
 +
**[[7jhp]] – hB-Raf BRS domain + Hras<br />
 +
**[[6ntc]], [[6ntd]] – hB-Raf BRS domain (mutant) + Hras<br />
**[[2l05]], [[5j17]], [[5j2r]] – hB-Raf RAS-binding domain - NMR<br />
**[[2l05]], [[5j17]], [[5j2r]] – hB-Raf RAS-binding domain - NMR<br />
**[[3ny5]] – hB-Raf RAS-binding domain <br />
**[[3ny5]] – hB-Raf RAS-binding domain <br />
**[[5j18]] – hB-Raf RAS-binding domain + inhibitor - NMR<br />
**[[5j18]] – hB-Raf RAS-binding domain + inhibitor - NMR<br />
 +
**[[6pts]], [[6ptw]] – hB-Raf 56-187 + Kras + apolipoprotein + GMPPNP - NMR<br />
**[[6uan]], [[6q0k]] – hB-Raf + 14-3-3 ζ – Cryo EM<br />
**[[6uan]], [[6q0k]] – hB-Raf + 14-3-3 ζ – Cryo EM<br />
**[[6nyb]] – hB-Raf + 14-3-3 ζ + MEK1 – Cryo EM<br />
**[[6nyb]] – hB-Raf + 14-3-3 ζ + MEK1 – Cryo EM<br />
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**[[2cdz]] – hChk Pak-4 + purine derivative<br />
**[[2cdz]] – hChk Pak-4 + purine derivative<br />
**[[2ov2]] – hChk Pak-4 CRIB domain + RAC3<br />
**[[2ov2]] – hChk Pak-4 CRIB domain + RAC3<br />
-
**[[2qon]], [[4fif]], [[4fih]], [[4fii]], [[4jdh]], [[4jdi]], [[4jdj]], [[4jdk]] – hChk Pak-4 kinase domain + peptide<br />
+
**[[2qon]], [[4fif]], [[4fih]], [[4fii]], [[4jdh]], [[4jdi]], [[4jdj]], [[4jdk]], [[6wlx]], [[6wly]] – hChk Pak-4 kinase domain + peptide<br />
**[[4app]], [[4o0v]], [[4o0x]], [[4o0y]], [[4njd]], [[4xbu]], [[5bms]], [[5i0b]], [[5vee]], [[5vef]], [[5zjw]], [[5xvg]], [[5xvf]], [[5xva]] – hChk Pak-4 kinase domain + inhibitor<br />
**[[4app]], [[4o0v]], [[4o0x]], [[4o0y]], [[4njd]], [[4xbu]], [[5bms]], [[5i0b]], [[5vee]], [[5vef]], [[5zjw]], [[5xvg]], [[5xvf]], [[5xva]] – hChk Pak-4 kinase domain + inhibitor<br />
**[[2x4z]], [[2xh5]] – hChk Pak-4 kinase domain (mutant) + inhibitor<br />
**[[2x4z]], [[2xh5]] – hChk Pak-4 kinase domain (mutant) + inhibitor<br />
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**[[4b9d]] - hChk Nek1 kinase domain (mutant) + inhibitor<br />
**[[4b9d]] - hChk Nek1 kinase domain (mutant) + inhibitor<br />
**[[2w5h]] – hChk Nek2 kinase domain<br />
**[[2w5h]] – hChk Nek2 kinase domain<br />
-
**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sk9]] – hChk Nek2 + inhibitor<br />
+
**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sk9]], [[6sgh]], [[6sgi]], [[6sgk]] – hChk Nek2 + inhibitor<br />
**[[2w5a]], [[2w5b]] – hChk Nek2 + nucleotide<br />
**[[2w5a]], [[2w5b]] – hChk Nek2 + nucleotide<br />
-
**[[2wqm]] – hChk Nek7<br />
+
**[[6tm5]] - hChk Nek2 in anaphase-promoting complex – Cryo EM<br />
 +
**[[2wqm]], [[6s76]] – hChk Nek7<br />
**[[2wqn]] – hChk Nek7 + ADP<br />
**[[2wqn]] – hChk Nek7 + ADP<br />
**[[5de2]] – hChk Nek7 + hChk Nek9<br />
**[[5de2]] – hChk Nek7 + hChk Nek9<br />
**[[6s73]], [[2wqo]] – hChk Nek7 + inhibitor<br />
**[[6s73]], [[2wqo]] – hChk Nek7 + inhibitor<br />
 +
**[[6npy]] – hChk Nek7 + Nlrp3<br />
 +
**[[6s75]] – hChk Nek7 + inhibitor<br />
*hChk Vrk (vaccinia-related kinase)
*hChk Vrk (vaccinia-related kinase)
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**[[3op5]] – hChk Vrk1 kinase domain (mutant)<br />
**[[3op5]] – hChk Vrk1 kinase domain (mutant)<br />
**[[5ukf]] – hChk Vrk1 kinase domain + inhibitor<br />
**[[5ukf]] – hChk Vrk1 kinase domain + inhibitor<br />
-
**[[5uvf]], [[6cnx]], [[6bu6]], [[6cfm]], [[6dd4]], [[6bp0]], [[6bru]], [[6btw]], [[6cmm]], [[6cqh]], [[6csw]] – hChk Vrk1 kinase domain (mutant) + inhibitor<br />
+
**[[5uvf]], [[6cnx]], [[6bu6]], [[6cfm]], [[6dd4]], [[6bp0]], [[6bru]], [[6btw]], [[6cmm]], [[6cqh]], [[6csw]], [[6vzh]] – hChk Vrk1 kinase domain (mutant) + inhibitor<br />
**[[6ac9]] – hChk Vrk1 kinase domain (mutant) + AMPPNP<br />
**[[6ac9]] – hChk Vrk1 kinase domain (mutant) + AMPPNP<br />
**[[2v62]] – hChk Vrk2 kinase domain <br />
**[[2v62]] – hChk Vrk2 kinase domain <br />
**[[5uu1]], [[6ncg]] – hChk Vrk2 kinase domain + inhibitor<br />
**[[5uu1]], [[6ncg]] – hChk Vrk2 kinase domain + inhibitor<br />
-
*Chk Wnk (protein kinase lysine-deficient)
+
*Chk Wnk (protein kinase lysine-deficient); Domains - kinase 194-483; CCT1 454-549
-
**[[6cn9]], [[4q2a]], [[4pwn]] - hChk Wnk1 kinase domain (mutant)<br />
+
**[[6cn9]], [[4q2a]], [[4pwn]], [[6ol2]] - hChk Wnk1 kinase domain (mutant)<br />
**[[5tf9]] - hChk Wnk1 kinase domain + inhibitor + AMPPNP<br />
**[[5tf9]] - hChk Wnk1 kinase domain + inhibitor + AMPPNP<br />
**[[5wdy]], [[5we8]] - hChk Wnk1 kinase domain + inhibitor + ANP<br />
**[[5wdy]], [[5we8]] - hChk Wnk1 kinase domain + inhibitor + ANP<br />
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**[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
**[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
**[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
**[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
-
**[[2lru]] – rChk Wnk1 autoinhibitory domain - NMR<br />
+
**[[2lru]] – rChk Wnk1 autoinhibitory domain 480-572 - NMR<br />
**[[5w7t]] - rChk Wnk1 kinase domain <br />
**[[5w7t]] - rChk Wnk1 kinase domain <br />
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**[[4efo]] – hChk Tbk1 ubiquitin-like domain <br />
**[[4efo]] – hChk Tbk1 ubiquitin-like domain <br />
-
**[[6rsr]] – hChk Tbk1 + inhibitor <br />
+
**[[6rsr]], [[6rsu]] – hChk Tbk1 + inhibitor <br />
**[[4im0]], [[4im2]], [[4im3]], [[4iw0]], [[4iwo]], [[4iwp]], [[4ipq]], [[6rst]] – hChk Tbk1 (mutant) + inhibitor <br />
**[[4im0]], [[4im2]], [[4im3]], [[4iw0]], [[4iwo]], [[4iwp]], [[4ipq]], [[6rst]] – hChk Tbk1 (mutant) + inhibitor <br />
**[[6cq5]], [[6cq4]], [[6cq0]], [[6boe]], [[6bod]], [[6bny]], [[5w5v]] – hChk Tbk1 + ulcer drug<br />
**[[6cq5]], [[6cq4]], [[6cq0]], [[6boe]], [[6bod]], [[6bny]], [[5w5v]] – hChk Tbk1 + ulcer drug<br />
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**[[2vuw]], [[2wb8]] – hChk Haspin kinase domain <br />
**[[2vuw]], [[2wb8]] – hChk Haspin kinase domain <br />
**[[3dle]] – hChk Haspin kinase domain + AMP<br />
**[[3dle]] – hChk Haspin kinase domain + AMP<br />
-
**[[3e7v]], [[3f2n]], [[3fmd]], [[3iq7]], [[4qtc]], [[5htb]], [[5htc]] – hChk Haspin kinase domain + inhibitor<br />
+
**[[3e7v]], [[3f2n]], [[3fmd]], [[3iq7]], [[4qtc]], [[5htb]], [[5htc]], [[6z56]], [[6z57]], [[6z58]], [[6z59]], [[6z5a]], [[6z5b]], [[6z5c]]. [[6z5d]], [[6z5e]] – hChk Haspin kinase domain + inhibitor<br />
**[[6g38]], [[6g34]], [[6g35]], [[6g36]], [[6g37]] – hChk Haspin kinase domain + tubercidin derivative<br />
**[[6g38]], [[6g34]], [[6g35]], [[6g36]], [[6g37]] – hChk Haspin kinase domain + tubercidin derivative<br />
**[[6g39]], [[6g3a]] – hChk Haspin kinase domain (mutant) + tubercidin derivative<br />
**[[6g39]], [[6g3a]] – hChk Haspin kinase domain (mutant) + tubercidin derivative<br />
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**[[6f7b]] – hChk Bub1 kinase domain + inhibitor<br />
**[[6f7b]] – hChk Bub1 kinase domain + inhibitor<br />
**[[4a1g]] – hChk Bub1 TPR domain + CASC5 KI motif<br />
**[[4a1g]] – hChk Bub1 TPR domain + CASC5 KI motif<br />
 +
**[[4ggd]] - hChk Bub1 + cell division cycle protein<br />
 +
**[[6tlj]], [[5khu]] - hChk Bub1 in anaphase-promoting complex – Cryo EM<br />
 +
**[[6jkk]] – DmChk Bub1 kinase domain <br />
 +
**[[6jkm]] – DmChk Bub1 kinase domain + ADP<br />
**[[5jja]] – hChk Bub1 residues 661-734 + PP2A<br />
**[[5jja]] – hChk Bub1 residues 661-734 + PP2A<br />
**[[3esl]] – yChk Bub1 N terminal <br />
**[[3esl]] – yChk Bub1 N terminal <br />
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**[[3fap]], [[2fap]], [[4fap]] – hFRAP FRB domain + FKBP + rapamycin analog<BR />
**[[3fap]], [[2fap]], [[4fap]] – hFRAP FRB domain + FKBP + rapamycin analog<BR />
**[[4drh]], [[4dri]], [[4drj]], [[5gpg]] – hFRAP FRB domain + FKBP + rapamycin<BR />
**[[4drh]], [[4dri]], [[4drj]], [[5gpg]] – hFRAP FRB domain + FKBP + rapamycin<BR />
 +
**[[6m4u]], [[6m4w]] – hChk Mtor FRB domain (mutant) + FKBP1A + rapamycin <br />
**[[5wbh]] – hFRAP FRB domain + S6K1 peptide <br />
**[[5wbh]] – hFRAP FRB domain + S6K1 peptide <br />
-
*''mTOR domain residues 1376-2549''
+
*''mTOR FAT+PIKK domain residues 1376-2549''
**[[4jsn]] – hFRAP + TORC subunit LST8<BR />
**[[4jsn]] – hFRAP + TORC subunit LST8<BR />
Line 470: Line 486:
**[[1zyd]] – yChk Gcn2 + ATP<br />
**[[1zyd]] – yChk Gcn2 + ATP<br />
**[[4otn]] – mChk Gcn2 C terminal domain <br />
**[[4otn]] – mChk Gcn2 C terminal domain <br />
 +
 +
*'''LRRK2''' or leucine-rich repeat Chk2
 +
 +
**[[6xr4]] – hLRRK2 – Cryo EM <br />
 +
**[[6oje]] – hLRRK2 GTPase domain 1329-1520<br />
 +
**[[6ojf]] – hLRRK2 GTPase domain (mutant) <br />
 +
**[[6dlo]], [[6dlp]] – hLRRK2 WD40 domain<br />
 +
**[[6vno]], [[6vp6]], [[6vp7]] – hLRRK2 C terminal 1330-2527 – Cryo EM <br />
 +
**[[6vp8]] – hLRRK2 C terminal 1330-2527 + COR domain 1670-1950 + WD40 domain 2140-2489 – Cryo EM <br />
 +
**[[6s6q]] – AtLRRK2 ectodomain + protein casparian strip peptide <br />
*'''Pim'''
*'''Pim'''
Line 475: Line 501:
*Pim1; Domains catalytic 14-313; kinase 92-404
*Pim1; Domains catalytic 14-313; kinase 92-404
-
**[[1xqz]], [[1ywv]], [[4jx3]] – hPim1 catalytic domain – human <br />
+
**[[1xqz]], [[1ywv]], [[4jx3]] – hPim1 catalytic domain <br />
**[[1yxs]] – hPim1 catalytic domain (mutant) <br />
**[[1yxs]] – hPim1 catalytic domain (mutant) <br />
**[[4jx3]] – hPim1 kinase domain <br />
**[[4jx3]] – hPim1 kinase domain <br />
Line 486: Line 512:
**[[2bzj]], [[2bzh]], [[2bzi]] – hPim1 catalytic domain (mutant) + organometallic ligand <br />
**[[2bzj]], [[2bzh]], [[2bzi]] – hPim1 catalytic domain (mutant) + organometallic ligand <br />
**[[2oi4]], [[3bwf]] – hPim1 kinase domain (mutant) + organometallic ligand <br />
**[[2oi4]], [[3bwf]] – hPim1 kinase domain (mutant) + organometallic ligand <br />
-
**[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[6bsk]], [[5v80]], [[5v82]]. [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]], [[6no8]], [[6no9]] – hPim1 kinase domain + inhibitor <br />
+
**[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[6bsk]], [[5v80]], [[5v82]]. [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]], [[6no8]], [[6no9]], [[6kzi]], [[6l11]], [[6l12]], [[6l13]], [[6l14]], [[6l15]], [[6l16]], [[6l17]], [[6ykd]] – hPim1 kinase domain + inhibitor <br />
**[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br />
**[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br />
**[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[4med]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]] – hPim1 catalytic domain + inhibitor <br />
**[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[4med]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]] – hPim1 catalytic domain + inhibitor <br />
Line 522: Line 548:
**[[6ul8]] – hRip2 catalytic domain (mutant) + inhibitor <br />
**[[6ul8]] – hRip2 catalytic domain (mutant) + inhibitor <br />
**[[6oko]] – mRip3 catalytic domain + inhibitor <br />
**[[6oko]] – mRip3 catalytic domain + inhibitor <br />
 +
**[[6jpd]] – mRip3 residues 409-486 - NMR <br />
**[[5wnm]], [[5wnj]] – mRip4 catalytic domain (mutant) + drug <br />
**[[5wnm]], [[5wnj]] – mRip4 catalytic domain (mutant) + drug <br />
**[[5wnl]] – mRip4 catalytic domain (mutant) + staurosporine <br />
**[[5wnl]] – mRip4 catalytic domain (mutant) + staurosporine <br />
Line 533: Line 560:
**[[5ci7]], [[6mnh]] – hChk Ulk1 (mutant) + inhibitor<br />
**[[5ci7]], [[6mnh]] – hChk Ulk1 (mutant) + inhibitor<br />
**[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
**[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
-
**[[6qav]], [[6qau]], [[6qat]] – hChk Ulk2 + inhibitor<br />
+
**[[6qav]], [[6qau]], [[6qat]], [[6yid]] – hChk Ulk2 + inhibitor<br />
**[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
**[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
**[[6fdz]], [[6fdy]] – hChk Ulk3 + leukemia drug<br />
**[[6fdz]], [[6fdy]] – hChk Ulk3 + leukemia drug<br />
Line 559: Line 586:
**[[3dak]] – hChk Osr1 kinase domain <br />
**[[3dak]] – hChk Osr1 kinase domain <br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
 +
**[[6l53]] – hChk Smg1 – Cryo EM <br />
 +
**[[6l54]], [[6syt]] – hChk Smg1 + Smg8 + Smg9 – Cryo EM <br />
 +
**[[6z3r]] – hChk Smg1 + Smg8 + Smg9 + regulator of nonsense transcripts – Cryo EM <br />
 +
**[[6kyq]] – hChk Dclk1 kinase domain<br />
 +
**[[6kyr]] – hChk Dclk1 kinase domain (mutant)<br />
**[[4pxw]] – hChk Vprbp WD repeat domain (mutant)<br />
**[[4pxw]] – hChk Vprbp WD repeat domain (mutant)<br />
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
Line 570: Line 602:
**[[5oat]] – rfbChk – red flour beetle <br />
**[[5oat]] – rfbChk – red flour beetle <br />
**[[4f0g]] – smChk Roco4 kinase domain – slime mold<br />
**[[4f0g]] – smChk Roco4 kinase domain – slime mold<br />
 +
**[[5tos]] – AtChk Bik1 <br />
**[[1q8z]], [[1zyc]] – yChk <br />
**[[1q8z]], [[1zyc]] – yChk <br />
**[[1how]], [[1zxe]], [[1zy4]] – yChk (mutant)<br />
**[[1how]], [[1zxe]], [[1zy4]] – yChk (mutant)<br />
Line 578: Line 611:
**[[5yyx]] – yChk Mek1 FHA domain <br />
**[[5yyx]] – yChk Mek1 FHA domain <br />
**[[6jxc]], [[6jxa]] – yChk Tel1 – Cryo EM<br />
**[[6jxc]], [[6jxa]] – yChk Tel1 – Cryo EM<br />
 +
**[[6rbd]], [[6y7c]] – yChk Rio2 in 40S particle – Cryo EM<br />
**[[6u69]] – CaChk Yck2 – ''Candida albicans''<br />
**[[6u69]] – CaChk Yck2 – ''Candida albicans''<br />
**[[6sl1]], [[6sl0]], [[6skz]], [[6sky]] – Chk Tel1 – ''Chaetonium thermophilum'' – Cryo EM<br />
**[[6sl1]], [[6sl0]], [[6skz]], [[6sky]] – Chk Tel1 – ''Chaetonium thermophilum'' – Cryo EM<br />
**[[6ra0]] – Chk Dkf1 – ''Chaenorhabditis elegans''<br />
**[[6ra0]] – Chk Dkf1 – ''Chaenorhabditis elegans''<br />
-
**[[5tos]] – AtChk Bik1 <br />
+
**[[6tlb]] – Chk – ''Plasmodium falciparum''<br />
*Other Chk complexes
*Other Chk complexes
Line 611: Line 645:
**[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br />
**[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br />
**[[5yj9]] – rfbChk Pink1 kinase domain + AMPPNP<br />
**[[5yj9]] – rfbChk Pink1 kinase domain + AMPPNP<br />
 +
**[[6bn1]] – DmChk Hippo SARAH domain + Shar-Pei<br />
**[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br />
**[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br />
 +
**[[3p86]], [[3ppz]] - AtChk Ctr1 + staurosporine<br />
**[[4f0f]] – smChk Roco4 kinase domain + APPCP <br />
**[[4f0f]] – smChk Roco4 kinase domain + APPCP <br />
**[[4f1m]], [[4f1o]] – smChk Roco4 kinase domain (mutant) + APPCP <br />
**[[4f1m]], [[4f1o]] – smChk Roco4 kinase domain (mutant) + APPCP <br />
Line 626: Line 662:
**[[5yyz]] – yChk Mek1 FHA domain + Hop1<br />
**[[5yyz]] – yChk Mek1 FHA domain + Hop1<br />
**[[5x6o]] – yChk Mec1 + LCD1 – Cryo EM<br />
**[[5x6o]] – yChk Mec1 + LCD1 – Cryo EM<br />
-
**[[6bn1]] – DmChk Hippo sarah domain + Shar-Pei<br />
 
-
**[[3p86]], [[3ppz]] - AtChk Ctr1 + staurosporine<br />
 
**[[6u6a]] – CaChk Yck2 + inhibitor<br />
**[[6u6a]] – CaChk Yck2 + inhibitor<br />
**[[5fvm]] – Chk Tor2 + LST8 – ''Kluyveromyces maximanus''<br />
**[[5fvm]] – Chk Tor2 + LST8 – ''Kluyveromyces maximanus''<br />

Revision as of 10:33, 2 November 2020

3D structures of serine/threonine protein kinase

Updated on 02-November-2020

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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