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6tj4
From Proteopedia
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==P. falciparum essential light chain, N-terminal domain== | ==P. falciparum essential light chain, N-terminal domain== | ||
| - | <StructureSection load='6tj4' size='340' side='right'caption='[[6tj4]]' scene=''> | + | <StructureSection load='6tj4' size='340' side='right'caption='[[6tj4]], [[Resolution|resolution]] 1.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TJ4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6tj4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TJ4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tj4 OCA], [http://pdbe.org/6tj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tj4 RCSB], [http://www.ebi.ac.uk/pdbsum/6tj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tj4 ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF3D7_1017500 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tj4 OCA], [http://pdbe.org/6tj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tj4 RCSB], [http://www.ebi.ac.uk/pdbsum/6tj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tj4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Gliding, a type of motility based on an actin-myosin motor, is specific to apicomplexan parasites. Myosin A binds two light chains which further interact with glideosome associated proteins and assemble into the glideosome. The role of individual glideosome proteins is unclear due to the lack of structures of larger glideosome assemblies. Here, we investigate the role of essential light chains (ELCs) in Toxoplasma gondii and Plasmodium falciparum and present their crystal structures as part of trimeric sub-complexes. We show that although ELCs bind a conserved MyoA sequence, P. falciparum ELC adopts a distinct structure in the free and MyoA-bound state. We suggest that ELCs enhance MyoA performance by inducing secondary structure in MyoA and thus stiffen its lever arm. Structural and biophysical analysis reveals that calcium binding has no influence on the structure of ELCs. Our work represents a further step towards understanding the mechanism of gliding in Apicomplexa. | ||
| + | |||
| + | Structural role of essential light chains in the apicomplexan glideosome.,Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Low C Commun Biol. 2020 Oct 13;3(1):568. doi: 10.1038/s42003-020-01283-8. PMID:33051581<ref>PMID:33051581</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6tj4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Loew C]] | + | [[Category: Plaf7]] |
| - | [[Category: Pazicky S]] | + | [[Category: Loew, C]] |
| + | [[Category: Pazicky, S]] | ||
| + | [[Category: Essential light chain]] | ||
| + | [[Category: Glideosome]] | ||
| + | [[Category: Motility]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Myosin]] | ||
Revision as of 20:47, 28 October 2020
P. falciparum essential light chain, N-terminal domain
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