3cxl

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Current revision (12:34, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3cxl' size='340' side='right'caption='[[3cxl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3cxl' size='340' side='right'caption='[[3cxl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3cxl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CXL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3cxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHN1, ARHGAP2, CHN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3cxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxl OCA], [http://pdbe.org/3cxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cxl RCSB], [http://www.ebi.ac.uk/pdbsum/3cxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxl OCA], [https://pdbe.org/3cxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxl RCSB], [https://www.ebi.ac.uk/pdbsum/3cxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN]] Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:[http://omim.org/entry/604356 604356]]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
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[https://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN] Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:[https://omim.org/entry/604356 604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN]] GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
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[https://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN] GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Buck, M]]
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[[Category: Buck M]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: MacKenzie, F]]
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[[Category: MacKenzie F]]
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[[Category: Park, H]]
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[[Category: Park H]]
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[[Category: Structural genomic]]
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[[Category: Shen L]]
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[[Category: Shen, L]]
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[[Category: Tempel W]]
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[[Category: Tempel, W]]
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[[Category: Tong Y]]
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[[Category: Tong, Y]]
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[[Category: Wilkstrom M]]
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[[Category: Wilkstrom, M]]
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[[Category: C1]]
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[[Category: Gtpase activation]]
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[[Category: Metal-binding]]
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[[Category: Phorbol-ester binding]]
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[[Category: Rho-gap]]
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[[Category: Sgc]]
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[[Category: Sh2]]
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[[Category: Sh2 domain]]
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[[Category: Signaling protein]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of human chimerin 1 (CHN1)

PDB ID 3cxl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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