1cvn

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{{STRUCTURE_1cvn| PDB=1cvn | SCENE= }}
{{STRUCTURE_1cvn| PDB=1cvn | SCENE= }}
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'''CONCANAVALIN A COMPLEXED TO TRIMANNOSIDE'''
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===CONCANAVALIN A COMPLEXED TO TRIMANNOSIDE===
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==Overview==
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Despite the fact that complex saccharides play an important role in many biological recognition processes, molecular level descriptions of protein-carbohydrate interactions are sparse. The legume lectin concanavalin A (con A), from Canavalia ensiformis, specifically recognizes the trimannoside core of many complex glycans. We have determined the crystal structure of a con A-trimannoside complex at 2.3-A resolution now describe the trimannoside interaction with conA. All three sugar residues are in well defined difference electron density. The 1,6-linked mannose residue is bound at the previously reported monosaccharide binding site; the other two sugars bind in an extended cleft formed by residues Tyr-12, Pro-13, Asn-14, Thr-15, and Asp-16. Hydrogen bonds are formed between the protein and all three sugar residues. In particular, the 1,3-linked mannose residue makes a strong hydrogen bond with the main chain of the protein. In addition, a water molecule, which is conserved in other con A structures, plays an important role in anchoring the reducing sugar unit to the protein. The complex is further stabilized by van der Waals interactions. The structure provides a rationale for the high affinity of con A for N-linked glycans.
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(as it appears on PubMed at http://www.pubmed.gov), where 8557713 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8557713}}
==About this Structure==
==About this Structure==
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[[Category: Concanavalin some]]
[[Category: Concanavalin some]]
[[Category: Saccharide binding]]
[[Category: Saccharide binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:09:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:30:58 2008''

Revision as of 18:31, 30 June 2008

Image:1cvn.png

Template:STRUCTURE 1cvn

CONCANAVALIN A COMPLEXED TO TRIMANNOSIDE

Template:ABSTRACT PUBMED 8557713

About this Structure

1CVN is a Single protein structure of sequence from Canavalia ensiformis. Full crystallographic information is available from OCA.

Reference

Structural basis of trimannoside recognition by concanavalin A., Naismith JH, Field RA, J Biol Chem. 1996 Jan 12;271(2):972-6. PMID:8557713

Page seeded by OCA on Mon Jun 30 21:30:58 2008

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