This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5yeq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:28, 22 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5yeq' size='340' side='right'caption='[[5yeq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='5yeq' size='340' side='right'caption='[[5yeq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5yeq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YEQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YEQ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5yeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YEQ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yeq OCA], [https://pdbe.org/5yeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yeq RCSB], [https://www.ebi.ac.uk/pdbsum/5yeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yeq ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yeq OCA], [http://pdbe.org/5yeq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yeq RCSB], [http://www.ebi.ac.uk/pdbsum/5yeq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yeq ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/A0A0U3H6N8_9CREN A0A0U3H6N8_9CREN]] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]
+
[https://www.uniprot.org/uniprot/ILVC_SULAC ILVC_SULAC] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Ketol-acid reductoisomerase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Chen, C Y]]
+
[[Category: Sulfolobus acidocaldarius]]
-
[[Category: Chiang, C H]]
+
[[Category: Chen CY]]
-
[[Category: Horng, J C]]
+
[[Category: Chiang CH]]
-
[[Category: Huang, C H]]
+
[[Category: Horng JC]]
-
[[Category: Ko, T P]]
+
[[Category: Huang CH]]
-
[[Category: Lin, B L]]
+
[[Category: Ko TP]]
-
[[Category: Lin, K F]]
+
[[Category: Lin BL]]
-
[[Category: Tsai, M D]]
+
[[Category: Lin KF]]
-
[[Category: Acid tolerant enzyme]]
+
[[Category: Tsai MD]]
-
[[Category: Ahir]]
+
-
[[Category: Bcaa]]
+
-
[[Category: Biofuel]]
+
-
[[Category: Branched-chain amino acid]]
+
-
[[Category: Isomerase]]
+
-
[[Category: Knot domain]]
+
-
[[Category: Metal ion cofactor]]
+
-
[[Category: Nadh]]
+
-
[[Category: Nadph]]
+
-
[[Category: Reductase]]
+

Current revision

The structure of Sac-KARI protein

PDB ID 5yeq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5yeq"
Personal tools